Functional Brain Imaging and Psychological Testing in Women With Chronic Pelvic Pain

Not Applicable

Withdrawn

• Conditions: Pelvis Pain Chronic; Endometriosis of Uterus
• Interventions: Other: Functional magnetic resonance imaging

• Registration Number: NCT02160483
• Lead Sponsor: KK Women's and Children's Hospital

Brief Summary

Functional magnetic resonance imaging in women with chronic pelvic pain using arterial spin labelling, functional connectivity, diffusion tensor imaging and magnetic resonance spectroscopy.

Detailed Description

Multimodal magnetic resonance neuroimaging will be utilised. Arterial spin labelling is tightly coupled with cerebral metabolism and can be used as a marker of neural activity. Resting state magnetic resonance imaging which measures synchronous activity across the brain, allows detection of functional connectivity of intrinsic brain network. Diffusion tensor imaging detects the anisotropic water diffusion in axonal fibres can provide information on connectivity and fibre tracts. Magnetic resonance spectroscopy would enable the levels of neurotransmitter to be elucidated.

Study Timeline

• Study First Submitted: 2014-05-25
• Study First Submitted QC: 2014-06-09
• Study First Posted: 2014-06-10
• Study Start: 2015-06
• Primary Completion: 2016-06
• Study Completion: 2016-06
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-18
• Last Update Posted: 2017-08-22

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

• Chronic pelvic pain
• Endometriosis

Exclusion Criteria

• Contraindication to magnetic resonance imaging

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Magnetic resonance imaging	Functional magnetic resonance imaging	Functional magnetic resonance imaging using arterial spin labelling, functional connectivity, diffusion tensor imaging, magnetic resonance spectroscopy to evaluate women with chronic pelvic pain and/ or endometriosis

Primary Outcome Measures

Name	Time	Method
Number of participants with increase in insula anterior cingulate cortex signal on magnetic resonance imaging	1 hour	Magnetic resonance imaging using arterial spin labelling, functional connectivity, diffusion tensor imaging, magnetic resonance imaging

Secondary Outcome Measures

Name	Time	Method
Number of subjects in psychological testing with increased anxiety, depression and pain catastrophizing scores	1 hour	Anxiety, depression and pain catastrophizing scales used for psychological testing

Trial Locations

Locations (1)

KK Women's and Children's Hospital; 🇸🇬 Singapore, Singapore