Modification of Posttetanic Count (PTC) for Monitoring Deep Neuromuscular Block II

Phase 4

Completed

• Conditions: Neuromuscular Blockade

• Registration Number: NCT00390507
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The purpose of this study is to examine the relationship between post-tetanic count (PTC) and time to first response to Train of four (TOF) stimulation during deep neuromuscular blockade induced by rocuronium.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-10
• Study First Submitted: 2006-10-19
• Study First Submitted QC: 2006-10-19
• Study First Posted: 2006-10-20
• Primary Completion: 2010-04
• Status Verified: 2010-09
• Last Update Submitted: 2010-09-02
• Last Update Posted: 2010-09-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• ASA 1-3
• General anaesthesia >1 hour
• Surgery in supine position with possibility of monitoring the neuromuscular blockade at the thumb (n.ulnaris stimulation).
• Written informed content

Exclusion Criteria

• Neuromuscular disorders, hepatic and renal dysfunction
• Medication expected to interfere with the neuromuscular blocking agent
• Allergy to any medication used during anaesthesia
• Body weight less or exceeding 20% of the ideal body weight
• Pregnancy or breastfeeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Time to first response to TOF stimulation (T1)

Secondary Outcome Measures

Name	Time	Method
Number of post-tetanic count at first response to TOF
Time to T1=25%
Time to TOF 0.9
Time to TOF 1.0
Time to second response to TOF stimulation (T2)
Time to first post-tetanic count (PTC)
Interval 25-75%

Trial Locations

Locations (2)

Dep. of Anesthesia, Rigshospitalet; 🇩🇰 Copenhagen, Denmark

Dep. of Anesthesia, Herlev hospital; 🇩🇰 Herlev, Denmark