Accurate delineation of glioma infiltration by advanced PET/MR neuro-imaging
Completed
- Conditions
- brain tumor10029211
- Registration Number
- NL-OMON45242
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
* Adult (18 years and older)
* MRI interpretation of diffuse infiltrative glioma by an expert neuroradiologist
* Indication for resective surgery confirmed by the multidisciplinary neuro-oncology workgroup
* Written informed consent
Exclusion Criteria
* Previous brain surgery, cranial radiotherapy or chemotherapy
* Other brain pathology on MRI, such as infarction or multiple sclerosis
* Tumor located infratentorially or in the spinal cord
* Estimated duration of surgery more than 440 minutes
* Pregnancy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Quantitative and qualitative imaging data from standard MRI (T1 without and<br /><br>with gadolinium, T2, 3D FLAIR), advanced MRI (DTI, perfusion-weighted MRI, MRS)<br /><br>and advanced PET (FET, CHO). Histopathological and molecular characterization<br /><br>of biopsy samples. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>