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Contribution of respiratory muscle strength and right ventricular pump function to exercise intolerance in patients with precapillary pulmonary hypertension

Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster0 个研究点目标入组 86 人开始时间: 2018年5月14日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•a. Age > 18 years (no age limit)
•b. able to consent
•c. Diagnosis of Nizza class I or IV precapillary pumonary Hypertension according to the most recent Guidelines of the European Society of Cardiology (ESC); >12 weeks since the diagnosis of PH has been made; no hospitalisation for HF in the last 4 weeks; optimal medical therapy in accordance with the most recent Guidelines of the European Society of Cardiology (ESC) with no change in medication in the last 4 weeks and combination therapy for PAH -where there was no treatment with combination therapy in PAH patients then the reason must be documented

•- secondary (postcapillary) pulmonary hypertension (mean pulmonary arterial hypertension > 25 mmHg; PCWP >15 mmHg)
•- other severe internistic pre-existing conditions, especially insulin-dependent diabetes or severe renal impairment
•- severe neurological pre-existing conditions such as stroke, especially brainstem infarction
•- intake of opioids
•- severe psychiatric pre-existing conditions
•- contraindications to (cardiac) magnetic resonance imaging (MRI)

发起方

Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster