Effect of Different Anaesthesia Drugs on Function of Heart
- Conditions
- Atherosclerotic heart disease of native coronary artery, (2) ICD-10 Condition: I060||Rheumatic aortic stenosis, (3) ICD-10 Condition: I350||Nonrheumatic aortic (valve) stenosis, (4) ICD-10 Condition: I712||Thoracic aortic aneurysm, withoutrupture,
- Registration Number
- CTRI/2018/07/014997
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research Chandigarh
- Brief Summary
A randomised, prospective, parallel group, multiple arm trial to evaluate and compare the changes in echocardiographic parameters of Left Ventricular Function upon induction of General anaesthesia by three different anaesthetic agents- Propofol, Etomidate and Sevoflurane. This trial has been planned as a thesis/dissertation, required for the degree of DM (Cardiac Anaesthesia) of Post Graduate Institute of Medical Education and Research, Chandigarh.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Patients of either sex of the age group 18-65 years, undergoing Coronary Artery Bypass Grafting/ Valve replacement or repair surgery/ Combined Coronary Artery Bypass Grafting and Valve surgery/ Combined Valve and ascending aortic procedure/ surgery for correction or palliation of congenital heart diseases.
- 1.Allergy to any of the drugs to be administered 2.
- Significant Mitral Annular Calcification 3.
- Regional dysfunction in the basal myocardial segments 4.
- Surgical rings or prosthetic mitral valves 5.
- Severe LV dysfunction (LVEF < 35%) 6.
- Pericardial disease 7.
- Poor echo window 8.
- Atrial fibrillation/Significant rhythm disturbance 9.
- H/o steroid use within last 6 months 10.
- H/o adrenal insufficiency 11.
- BMI> 35 kg/m2.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate and compare the effects of anaesthetic induction by Propofol, Etomidate and Sevoflurane on the echocardiographic parameters of Left Ventricular Function (Peak Global Longitudinal Strain, Septal and Lateral Mitral Annular S’) in adult patients undergoing cardiac surgeries. 1. Baseline | 2. Post Induction (Upon reaching target BIS of 50) | 3. Post Intubation (Within 1 minute after endotracheal intubation)
- Secondary Outcome Measures
Name Time Method To evaluate and compare the effects of anaesthetic induction by Propofol, Etomidate and Sevoflurane on the echocardiographic parameters of cardiac preload (LVEDVI), cardiac afterload (Ea), Left ventricular function (LV ejection fraction, Septal and Lateral Mitral Annular ’, E’, A’ velocities, Tei Index, P/V Ratio), Mitral inflow velocities (E velocity, A velocity, E wave deceleration time). 1. Baseline To observe any side effects of the anaesthetic agents used Throughout during the Induction and Intubation period To find out correlation between the change in preload and afterload parameters (EDVI, Ea, SVRI) respectively and the change in the systolic function parameters (Peak Global Longitudinal Strain, EF, Tei Index, Septal and Lateral Mitral Annular S’ velocities, P/V ratio) from baseline to that after induction From baseline to after induction
Trial Locations
- Locations (1)
Advanced Cardiac Centre, Post Graduate Institute of Medical Education and Research, Chandigarh
🇮🇳Chandigarh, CHANDIGARH, India
Advanced Cardiac Centre, Post Graduate Institute of Medical Education and Research, Chandigarh🇮🇳Chandigarh, CHANDIGARH, IndiaDr Indranil BiswasPrincipal investigator7710449858hreesheekombartta@gmail.com