Time Restricted Fasting and Aerobic Exercise Interventions Among Sedentary Adults
- Conditions
- Sedentary; Aging
- Interventions
- Behavioral: Aerobic ExerciseBehavioral: Time Restricted Fasting
- Registration Number
- NCT05865639
- Lead Sponsor
- Guangzhou Sport University
- Brief Summary
This project will determine the independent and combined effects of aerobic exercise and time restricted fasting on cardiovascular risks among sedentary middle-aged and elderly adults. The online intervention period will be eight weeks. Before and after the intervention, arterial stiffness, cardiac autonomic nervous, body composition, glucolipid metabolism, sleep and eating habits, inflammatory reaction, sedentary behavior and physical activity level will be measured and compared between groups who are doing either aerobic exercise, time restricted fasting, both aerobic exercise and time restricted fasting, or who are in a control group. Adverse reaction, sleep and eating quality, life quality and adherence to the interventions and hunger/satiety will also be measured.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 56
- Age: 45-69 years old Sedentary time ≥8 hours per day
- Irregular exercise habits
- No drugs affecting the outcome index were taken
- No history of serious diseases
- Sign the subject informed consent and agree to participate in this experiment.
- The range of body weight change in the last three months is more than 3kg
- People taking weight-loss drugs
- Participate in other experimenters 5 months before the experiment
- Unable to adjust and follow the intervention schedule.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Aerobic Exercise Aerobic Exercise Aerobic exercise for eight weeks. Three weekly, supervised training sessions. Time Restricted Fasting Time Restricted Fasting Time restricted fasting for eight weeks. Maximal daily eating window of 8 hours. Aerobic exercise & Time Restricted Fasting Aerobic Exercise - Aerobic exercise & Time Restricted Fasting Time Restricted Fasting -
- Primary Outcome Measures
Name Time Method Change of cardiovascular risk estimated by ankle-brachial index From baseline to after 8 weeks intervention Change of cardiovascular risk estimated by heart rate variability From baseline to after 8 weeks intervention Change of cardiovascular risk estimated by pulse wave velocity From baseline to after 8 weeks intervention Change of cardiovascular risk estimated by flow-mediated transition From baseline to after 8 weeks intervention Change of cardiovascular risk estimated by cytokines level From baseline to after 8 weeks intervention Fasting matrix metalloproteinases, norepinephrine, and neuropeptide Y cytokines level in blood
- Secondary Outcome Measures
Name Time Method Triglycerides in blood From baseline to after 8 weeks intervention Fasting triglycerides in blood
Sleep quality From baseline to after 8 weeks intervention Self-reported: sleep quality was indicated by the Pittsburgh Sleep Quality Index (PSQI) Questionnaire. The maximum score of the sleep quality index is 21 points,scores higher than 5 indicate poor sleep quality, with higher scores indicating poorer sleep quality.
Physical activity From baseline to after 8 weeks intervention Physical activity were measured by using accelerometer (ActiGraph GT3X+ model, USA).Measured by using accelerometer (ActiGraph GT3X+ model, USA). Accelerometer was used for 7 consecutive days, being affixed to the nondominant wrist.
Weight From baseline to after 8 weeks intervention In kg
body fat From baseline to after 8 weeks intervention In kg
Diet habits From baseline to after 8 weeks intervention Self-reported: diet habits were assessed using the Adult Eating Behavior Questionnaire (AEBQ).
With higher scores indicating worse eating habits (represented by emotional over-eating and emotional under-eating) or better dietary (represented by food responsiveness, enjoyment of food, satiety responsiveness, food fussiness and slowness in eating).Adherence to intervention From baseline to after 8 weeks intervention Self-reported: WeChat application, number of completed exercise sessions out of those prescribed, in percentage.
Lean body mass From baseline to after 8 weeks intervention In kg
Body fat percentage From baseline to after 8 weeks intervention In percent of total body mass
Life quality From baseline to after 8 weeks intervention Self-reported: life quality was indicated by The World Health Organization Quality of Life (WHOQOL)-BREF Questionnaire. With higher scores indicating better life quality.
Cholesterol in blood From baseline to after 8 weeks intervention Total fasting cholesterol in blood
Diet in take From baseline to after 8 weeks intervention Self-reported: Mint Health application.
Body mass Index From baseline to after 8 weeks intervention In kg/m\^2
Low density lipoprotein in blood From baseline to after 8 weeks intervention Fasting low density lipoprotein in blood
Sedentary activity From baseline to after 8 weeks intervention Sedentary activity were measured by using accelerometer (ActiGraph GT3X+ model, USA).Measured by using accelerometer (ActiGraph GT3X+ model, USA). Accelerometer was used for 7 consecutive days, being affixed to the nondominant wrist.
Inflammation level From baseline to after 8 weeks intervention Inflammation level were measured by Enzyme-linked immuno sorbent.
High density lipoprotein in blood From baseline to after 8 weeks intervention Fasting high density lipoprotein in blood
Adverse reaction From baseline to after 8 weeks intervention Self-reported: mini program.
Trial Locations
- Locations (1)
Guangzhou Sport University
🇨🇳Guangdong, Guangzhou, China