A randomized, double-blind controlled study of Zhichan granules in the treatment of Parkinson's disease
- Conditions
- Parkinson's Disease
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) Meeting the diagnostic criteria for Parkinson's disease;
(2) Aged between 40 and 80 years;
(3) Patients with grade 3 or below according to the improved Hoehn-Yahr grading method;
(4) Meeting the criteria for diagnosis of TCM syndrome of liver-kidney Yin deficiency or deficiency of qi and blood.
(5) TCM syndrome score >= 10.
(6) Those who sign the informed consent.
(1) Those who had undergone cell knife surgery in the half year before the experiment;
(2) Patients with severe hypertension (blood pressure >180/120), and poor blood pressure?control;
(3) Mental illness, epilepsy, pregnant women and lactating women;
(4) Patients with severe cerebral arteriosclerosis, cerebrovascular disease and?the resultant limb dysfunction;
(5) Patients with severe heart failure, kidney failure, abnormal liver function, bone disease, etc. that affect the evaluation of the curative effect of this disease;
(6) Alcoholism, drug addiction or severe mental impairment (including severe alzheimer's disease), thus unable to take drugs on time and cooperating with the examination;
(7) Participants in other clinical trials in recent 2 months;
(8) Patients with Parkinson's syndrome and Parkinson's superimposed syndrome;
(9) Allergic constitution and allergic to known ingredients of test and control drugs.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MS Quest;UPDRS;NMSS;
- Secondary Outcome Measures
Name Time Method BDNF;IL;MDA;SOD;8-OHdG;TNF-alpha;Alpha-synuclein;