Comparison of the Effects of Single Versus Triple Injections of Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Not Applicable

Completed

• Conditions: Knee Osteoarthritis
• Interventions: Other: prp injection

• Registration Number: NCT06408922
• Lead Sponsor: Izmir Democracy University

Brief Summary

80 patients diagnosed with knee osteoarthritis were randomized into two groups: patients in Group 1 received a single intraarticular injection of PRP whereas those in group 2 were administered three intraarticular injections of PRP within an interval of 2 weeks between each application. Patients were evaluated before the treatment and at the 6 month after the treatment with a Visual Analog Scale (VAS) and The Western Ontario and MacMaster Universities (WOMAC) Osteoarthritis Index.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-04-15
• Primary Completion: 2024-04-01
• Study Completion: 2024-04-15
• Status Verified: 2024-05
• Study First Submitted: 2024-05-07
• Study First Submitted QC: 2024-05-07
• Last Update Submitted: 2024-05-07
• Study First Posted: 2024-05-10
• Last Update Posted: 2024-05-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• ages of 35 and 80
• Kellgren-Lawrence grade of 2, 3, or 4

Exclusion Criteria

• rheumatic diseases, coagulopathies, severe cardiovascular diseases, local infections, malignancies, immunodeficiency, schizophrenia, mental retardation, anticoagulant therapy, a hemoglobin concentration of 11 g/dL and platelets of 150,000/L, a history of severe trauma, or a history of hyaluronic acid or corticosteroid injection within the previous 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Single prp injection	prp injection	single intraarticular prp injection
triple prp injection	prp injection	triple intraarticular prp injection

Primary Outcome Measures

Name	Time	Method
The Western Ontario and MacMaster Universities (WOMAC) Osteoarthritis Index	baseline and 6 months

Secondary Outcome Measures

Name	Time	Method
Visual Analog Scale (VAS)	baseline and 6 months

Trial Locations

Locations (1)

Buca Seyfi Demirsoy Training and Research Hospital; 🇹🇷 Izmir, Turkey