Brain activation during sentence processing in Parkinson's disease: an event related fMRI-study.

• Conditions: onbekend; 10028037; 10010118

• Registration Number: NL-OMON29824
• Lead Sponsor: Rijksuniversiteit Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

Parkinson*s disease

Exclusion Criteria

dementia, depression, other neurological or psychiatric disorders

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>For the fMRI analysis data, a main effect of group is expected. The level of<br /><br>activation in the BG will be reduced in the PD patient group compared to the<br /><br>healthy control group. For the within subject factors we expect to find a main<br /><br>effect of grammaticality. In the healthy elderly subject group, we expect that<br /><br>the processing of the grammatical incorrect sentences will activate the BG more<br /><br>compared to the processing of the grammatical correct sentences. For the<br /><br>behaviourally data, we expect to find slower reaction times (RTs) for the<br /><br>processing of non-canonical ungrammatical sentences (i.e. passive sentences<br /><br>with a violation) in both subject groups. However the RTs will be significantly<br /><br>more affected in the PD group compared to the healthy elderly subject group.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable!</p><br>