Brain activation during sentence processing in Parkinson's disease: an event related fMRI-study.
Completed
- Registration Number
- NL-OMON27976
- Lead Sponsor
- niversity of Groningen, Faculty of Arts, Neurolinguistics
- Brief Summary
Presentations on conferences and articles in scientific journals.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 32
Inclusion Criteria
1. Idiopathic Parkinson's Disease (PD)
2. Hoehn and Yahr Stage 1 to Stage 3
Exclusion Criteria
1. Not optimally medicated
2. Neurostimulator
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method For the fMRI analysis data, a main effect of group is expected. The level of activation in the BG will be reduced in the PD patient group compared to the healthy control group. For the within subject factors we expect to find a main effect of grammaticality. In the healthy elderly subject group, we expect that the processing of the grammatical incorrect sentences will activate the BG more compared to the processing of the grammatical correct sentences. For the behaviourally data, we expect to find slower reaction times (RTs) for the processing of non-canonical ungrammatical sentences (i.e. passive sentences with a violation) in both subject groups. However the RTs will be significantly more affected in the PD group compared to the healthy elderly subject group.
- Secondary Outcome Measures
Name Time Method