A trial to evaluate the effects of a D-xylose preload, with or without sitagliptin, on incretin hormone secretion, gastric emptying, and postprandial glycaemia in patients with type 2 diabetes mellitus.
Not Applicable
Completed
- Conditions
- Type 2 diabetes mellitusMetabolic and Endocrine - Diabetes
- Registration Number
- ACTRN12612001131842
- Lead Sponsor
- Royal Adelaide Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Patients with type 2 diabetes mellitus
Exclusion Criteria
Medications affecting gut function; Alcohol intake >20g daily or cigarette smoking; Significant gastrointestinal disease or surgery; Impaired liver or renal function; Blood donation within 3 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood glucose concentration[T = -40, -20, 0, 15, 30, 60, 90, 120, 180 and 240 min]
- Secondary Outcome Measures
Name Time Method Plasma active GLP-1 concentration[T = -40, -20, 0, 15, 30, 60, 90, 120, 180 and 240 min];Gastric half-emptying time measured by breath test after labelling the potato meal with 13C octanoic acid[Breath samples at immediately before the potato meal and then every 5 min for the first hour after, then every 15 min for a further 3 hours.]