we are comparing effect of etomidate,propofol and combination of propofol and ketamine on patients vitals at start of anaesthesia

Completed

• Conditions: ASA grade I and II age 18-60yrs both male and female all elective general surgery

• Registration Number: CTRI/2018/04/013409
• Lead Sponsor: Department of anaesthesiology

Brief Summary

comparing propofol,etomidate and ketofol as an induction agent and to compare haemodynamic changes during induction and intubation with etomidate, propofol and ketamine +propofol (ketofol) and to evaluate any adverse effects of study drugs.We Concluded that combination of ketamine plus propofol has better haemodynamic stability than etomidate and propofol as an induction agent with no side effects. Hence, combination proved to be significantly better than either propofol or etomidate alone

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12-16
• Study Completion: 2017-12-17
• Last Update Posted: 2021-02-02

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

American society of Anaesthesiologist grade I and II of either sex, weighing 35-70kg elected for general surgeries under general anaesthesia.

Exclusion Criteria

Patients with history ofadrenal insufficiency, asthma,hypertension,suspected difficult airway, receiving general anaesthesia during the previous week,receiving steroid during the past 6 months,sensitivity to etomidate, propofol or ketamine,sensitivity to egg and soya,pregnancy, Morbidly obese,chronic inflammatory diseases and serious psychiatric,endocrine or neurological illnesses.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
comparision of haemodynamics in three groups	Haemodynamics were recorded baseline value,after induction,0 min after intubation,1 minute after intubation, 3 min after intubation, 5 min after intubation and 10 min after intubation

Secondary Outcome Measures

Name	Time	Method
comparison of side effects and any adverse effects	any adverse effects of drug like pain on injection and myoclonus movement was seen during induction

Trial Locations

Locations (1)

MB governmentt hospital; 🇮🇳 Udaipur, RAJASTHAN, India

MB governmentt hospital

🇮🇳Udaipur, RAJASTHAN, India

Meenakshi machhar

Principal investigator

9929760889

meenakshimachhar25@gmail.com