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临床试验/NCT06412302
NCT06412302已完成不适用

No-Whey: High Protein Dairy and Resistance Exercise for the Improvement of Body Composition and Muscle Function in the Elderly

Universidad de O´Higgins1 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2023年6月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
18
试验地点
1
主要终点
Blood Lipids

研究概览

简要总结

Protein supplementation is one of the main recommendations for regular endurance physical exercise (RT). In older people, the need for protein increases particularly in the face of physiological and pathophysiological changes associated with the loss of muscle tissue and function, so protein intake becomes more relevant in this population. Fermented dairy products such as yogurt, and especially those with an extra protein content, have increased their popularity and consumption in the national market. Their nutritional composition is of particular interest, given their amino acid profile and in particular their high Leucine content, which could be compared with the classic protein supplements recommended for muscle gain and recovery. Objective: To analyze the effect on body composition, lipid profile, physical condition and muscle functionality induced by the intake of high protein yogurts versus Whey protein together with a muscular resistance program in elderly people. Hypothesis: The intake of high protein yogurts will lead to equal or greater gains in muscle mass, physical condition and functionality than those obtained with the intake of Whey protein together with resistance training in elderly people.Methodology: 16 healthy, lactose intolerant free, older (60-75 years old) subjects will be recruited to perform 8 weeks of muscular resistance training (RT) 3 times per week, who will be randomly supplemented with high protein yogurt (PY) or Whey protein (WP). At baseline and at the end of the intervention, body composition will be assessed by DEXA, muscle strength, maximal oxygen consumption and lipid profile. Expected Results: The YPRT group is expected to achieve similar or greater increases in muscle strength, fat-free mass, lipid profile and decrease in fat mass than the WP group.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Participant)

入排标准

年龄范围
60 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •>60 years
  • •Less than 1 hour of exercise a week

排除标准

  • •Lactose Intolerant
  • •Type 1 or 2 Diabetes
  • •Alcohol intake
  • •Currently taking protein, high protein yogurts, creatine, HMB or any other supplement that aims to improve muscle mass

研究组 & 干预措施

Whey Protein+Resistance Training

Experimental

Participants will undergo 8 weeks of resistance training and receive a whey protein shake after each exercise session.

干预措施: Whey Protein+Resistance Training (Other)

Protein Yogurt+Resistance Training

Experimental

Participants will undergo 8 weeks of resistance training and receive a yogurt shake after each exercise session.

干预措施: High protein yogurt+Resistance Training (Other)

结局指标

主要结局

Blood Lipids

时间窗: From Baseline, up to 56 days

Changes on Serum Triglycerides, Total Cholesterol, and High Density Cholesterol (mmol/L)

Muscle Strength

时间窗: From Baseline, up to 56 days

Determine by Isometric mid-tight pull (Newton, N)

Time Up and Go

时间窗: From Baseline, up to 56 days

Length of time from sitting-walk-sit (seconds)

Isokinetic Muscle Strength

时间窗: From Baseline, up to 56 days

Maximal peak torque from left and right quadriceps and hamstrings (N/m)

Body Composition

时间窗: From Baseline, up to 56 days

Changes in weight, total fat mass, total skeletal muscle mass, segmental fat and muscle mass

Handgrip

时间窗: From Baseline, up to 56 days

Handgrip Strength measured on left and right hand (kg)

Aerobic Capacity

时间窗: From Baseline, up to 56 days

Maximal Oxygen Consumption determine by the volume of oxygen (L/min)obtained on a incremental test

Evaluation of the intestinal microbiota

时间窗: From Baseline, up to 56 days

Fecal microbiota analysis based on the 16S ribosomal RNA (rRNA) sequencing pre- and post-dietary intervention.

Resting Metabolic Rate

时间窗: From Baseline, up to 56 days

Determine by indirect calorimetry (kcal/d)

次要结局

  • Food Consumption(From Baseline, up to 56 days)
  • Evaluation of liver characteristics profile(From Baseline, up to 56 days)

研究者

发起方
Universidad de O´Higgins
申办方类型
Other
责任方
Principal Investigator
主要研究者

Matias Monsalves Álvarez

Principal Investigator

Universidad de O´Higgins

研究点 (1)

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