NCT02963298已完成不适用
Pilot Trial Concerning Glutamate Elimination With CRRT for Neurological Outcome After Cardiac Arrest
C. Storm2 个研究点 分布在 1 个国家目标入组 42 人开始时间: 2016年10月最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- Glutamate blood concentration in intervention arm over the time
研究概览
简要总结
Glutamate is known to be a mediator for apoptosis after brain hypoxia e.g. due to cardiac arrest. This pilot trial evaluates the possibility of elimination of Glutamate by CRRT after cardiac arrest.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •post cardiac arrest
排除标准
- •hemodynamic instable
- •in-hospital cardiac arrest
研究组 & 干预措施
CRRT after cardiac arrest
Active Comparator
Continuous renal replacement therapy (CRRT) after cardiac arrest for 72 hours for elimination of Glutamate. Repetitive testing of blood Glutamate levels.
干预措施: Continuous renal replacement therapy (Procedure)
control
No Intervention
Repetitive testing of blood Glutamate levels without CRRT
结局指标
主要结局
Glutamate blood concentration in intervention arm over the time
时间窗: 72 hours
Reduction of blood Glutamate concentration by renal replacement therapy
次要结局
- number of participants with abnormal outcome parameters(up to 14 days)
研究者
C. Storm
PD Dr. med.
Charite University, Berlin, Germany
研究点 (2)
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