Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise

Not Applicable

• Conditions: Adults; BMI>35
• Interventions: Other: cycling exercises

• Registration Number: NCT02938117
• Lead Sponsor: University Hospital, Clermont-Ferrand

Brief Summary

Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition

Detailed Description

Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric end isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Study Timeline

• Status Verified: 2016-10
• Study First Submitted: 2016-10-10
• Study First Submitted QC: 2016-10-17
• Last Update Submitted: 2016-10-17
• Study First Posted: 2016-10-19
• Last Update Posted: 2016-10-19
• Study Start: 2017-01
• Primary Completion: 2019-12
• Study Completion: 2020-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• • Adults
• Obese (BMI>35)
• Inactive (<10 METS/h/week)
• No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity

Exclusion Criteria

• (BMI<35)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CON : concentric cycling exercise	cycling exercises	Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise
EXC : eccentric cycling exercise	cycling exercises	Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise

Primary Outcome Measures

Name	Time	Method
change in total body fat mass (Dual X ray Absorptiometry)	before and after the 12 weeks training program

Secondary Outcome Measures

Name	Time	Method
aerobic capacities (VO2max)	before and after the 12 weeks training program
isometric muscular lower limbs strength	before and after the 12 weeks training program
isokinetic muscular lower limbs strength	before and after the 12 weeks training program
rest energy expenditure (indirect calorimetry)	before and after the 12 weeks training program
biological parameters (plasma lipid profile)	before and after the 12 weeks training program
biological parameters (insulin-resistance)	before and after the 12 weeks training program
physical activity	before and after the 12 weeks training program	(actimetry)
food intakes	before and after the 12 weeks training program	(questionnaires)
quality of life (questionnaires)	before and after the 12 weeks training program
segmental body composition	before and after the 12 weeks training program	(segmental fat and fat free mass)

Trial Locations

Locations (1)

CHU Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France