Influence of two different perioperative intravenous fluid regimens on perioperative Interleukin 6 (IL-6) levels and total antioxidant status in patients undergoing laparoscopic cholecystectomy
Not Applicable
- Conditions
- Fluid management during laparoscopic cholecystectomyOxidative stress and immune response in acordance to fluid management during laparoscopic cholecystectomy
- Registration Number
- DRKS00009881
- Lead Sponsor
- General Hospital Karlovac
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
ASA (American Society of Anesthesiology) status I and II (low perioperative risk patients) patients that will undergo laparoscopic cholecystectomy
Exclusion Criteria
Patients younger than 18 and older than 65 years of age will be excluded from study.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To analyse perioperative changes in total antioxidant status (TAS) and IL-6 plasma levels in accordance to restrictive or liberal perioperative volume management, assessed before operation, at the time of reaching pneumoperitoneum, 6 hours after surgery and 24 hours after surgery.
- Secondary Outcome Measures
Name Time Method To analyse perioperative hemodynamic stability by continuous monitoring of Systolic (SAP), Diastolic (DAP) and mean arterial blood pressure (MAP), Heart rate, Stroke Volume and Cardiac Output Dynamic Preload parameters (Pulse Pressure Variation (PPV) and Stroke Volume Variation (SVV)) in accordance to restrictive or liberal volume management.