Study of Effects of Vitamin D on expression of some of genes in MS patient
Not Applicable
- Conditions
- multiple sclerosis.Multiple sclerosis
- Registration Number
- IRCT2014011216181N1
- Lead Sponsor
- Tarbiat Modares University of Tehrean
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
relapsing-remitting multiple sclerosis patients; MS patients with vitamin D deficiency (<80ng/ml).
Exclusion criteria: patients treated with vitamin D supplements; progressive MS; relapsed patients.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expression of IL10 gene. Timepoint: before vitamin D treatment and two month after treatment. Method of measurement: obtain of blood from patients and measurment of mRNA level.;Expression of TGF-B1 gene. Timepoint: before vitamin D treatment and two month after treatment. Method of measurement: obtain of blood from patients and measurement of mRNA level.;Expression of TGF-B2, TGF-B receptor I, TGFB receptor II, NF-KB, VDR gene. Timepoint: before vitamin D treatment and two month after treatment. Method of measurement: obtain of blood from patients and measurement of mRNA level.;Serum vitamin D. Timepoint: before vitamin D treatment and two month after treatment. Method of measurement: obtain of blood from patients and measurement of serum vitamin D level.
- Secondary Outcome Measures
Name Time Method