Assisted Hatching Versus Endometrial Scratch in Recurrent Implantation Failure

Not Applicable

• Conditions: Recurrent Implantation Failure
• Interventions: Procedure: controlled ovarian hyperstimulation; Procedure: endometrial scratch; Procedure: assisted hatching

• Registration Number: NCT02752568
• Lead Sponsor: Kasr El Aini Hospital

Brief Summary

300 recurrent implantation failure patients will be alternatively assigned to assisted hatching , endometrial scratch , and no treatment ,100 patients in each group

Detailed Description

Group 1 consists of 100 patients will undergo endometrial scratch followed by controlled ovarian hyperstimulation Group 2 consists of 100 patients will undergo controlled ovarian hyperstimulation\& assisted hatching Group 3 consists of 100 patients will undergo controlled ovarian hyperstimulation

Study Timeline

• Status Verified: 2016-04
• Study First Submitted: 2016-04-25
• Study First Submitted QC: 2016-04-26
• Last Update Submitted: 2016-04-26
• Study First Posted: 2016-04-27
• Last Update Posted: 2016-04-27
• Study Start: 2016-05
• Primary Completion: 2016-11
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 300

Inclusion Criteria

• recurrent implantation failure
• normal uterine cavity by transvaginal ultrasound

Exclusion Criteria

• endometrial polyp or fibroid distorting the endometrium
• hydrosalpinx
• preimplantation genetic diagnosis
• severe male factor

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
ovarian stimulation only group	controlled ovarian hyperstimulation	controlled ovarian hyperstimulation
Endometrial scratch group	controlled ovarian hyperstimulation	endometrial scratch controlled ovarian hyperstimulation
Assisted hatching group	controlled ovarian hyperstimulation	assisted hatching controlled ovarian hyperstimulation
Endometrial scratch group	endometrial scratch	endometrial scratch controlled ovarian hyperstimulation
Assisted hatching group	assisted hatching	assisted hatching controlled ovarian hyperstimulation

Primary Outcome Measures

Name	Time	Method
number of patients with positive pregnancy test	2 months