Delivery of Anxiety Disorder Treatment in Addictions Centers

Not Applicable

Completed

• Conditions: Anxiety Disorders; Substance Use Disorders
• Interventions: Behavioral: Treatment as usual; Behavioral: CALM-SUD

• Registration Number: NCT01764698
• Lead Sponsor: University of California, Los Angeles

Brief Summary

Anxiety disorders are highly prevalent among those with substance use disorders, but the majority of addictions treatment centers provide little to no evidence-based treatment for anxiety disorders. Furthermore, tension reduction models suggest that treating anxiety should also improve substance use outcomes. This study is aimed at improving symptoms for people who have substance use and anxiety problems. The study is comparing regular Intensive Outpatient treatment for addiction to Intensive Outpatient treatment for addiction plus treatment for anxiety disorders. Clinicians at a community addictions clinic will participate by receiving training in delivering cognitive behavioral therapy for anxiety disorders and will deliver the treatment to the patient participants. They will also complete some questionnaires. Patient participants will be asked to complete a baseline assessment. Those who are eligible will be randomly assigned to one of the two treatment groups. Those who are assigned to addiction treatment as usual will continue their regular care at the Matrix Institute. Participants who are assigned to also receive the anxiety treatment will be asked to participate in 6, 90-min treatment sessions and an orientation session. All participants will be asked to complete post-treatment and follow-up assessments. The assessments should take approximately 1 hour, and the follow-up assessment will be completed 6 months after treatment is over. It is hypothesized that those who get the additional anxiety disorder treatment will show greater improvement in anxiety and substance use outcomes than those who get Intensive Outpatient Program without the anxiety disorder treatment.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2012-12-17
• Study First Submitted QC: 2013-01-07
• Study First Posted: 2013-01-09
• Study Start: 2013-11-15
• Primary Completion: 2016-11-15
• Study Completion: 2016-11-15
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-24
• Last Update Posted: 2017-10-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• 18-60 years old
• speak English
• meet diagnostic criteria for at least one anxiety disorder
• score at least an 8 on the OASIS (see Assessments), indicating at least moderate but clinically significant anxiety symptoms
• be enrolled in the Intensive Outpatient Program (IOP) at the Matrix Institute (community partner)
• meet diagnostic criteria for substance abuse or dependence

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Exclusion Criteria

• have unstable medical conditions
• marked cognitive impairment
• active suicidal intent or plan
• active psychosis
• unstable Bipolar I disorder.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Treatment as usual	Treatment as usual	Participants in this arm receive the standard Intensive Outpatient treatment for their substance use disorder at a community addictions treatment facility.
CALM-SUD	CALM-SUD	Participants receive the adaptation of the Coordinated Anxiety Learning and Management (CALM) protocol that demonstrated effectiveness in a large primary care sample. CALM will be adapted for those with anxiety and substance use disorder comorbidity, and will consist of an orientation session and 6 group treatment sessions. These participants will also receive substance abuse treatment as usual at a community Intensive Outpatient Program.

Primary Outcome Measures

Name	Time	Method
Brief Symptom Inventory	baseline, 6 weeks, 6 months	Change over time is being assessed.
Timeline Follow Back	baseline, 6 week, 6 month	Change over time is being assessed
Overall Anxiety Severity and Impairment Scale	baseline, 6 week, 6 month	Change over time is being assessed.

Secondary Outcome Measures

Name	Time	Method
Posttraumatic Stress Disorder Checklist	baseline, 6 week, 6 month	Change over time is being assessed.
Social Phobia Inventory	baseline, 6 week, 6 month	Change over time is being assessed.
urine toxicology screen	baseline, 6 week, 6 month	Change over time is being assessed.
Patient Health Questionnaire-8	baseline, 6 week, 6 month	brief depression measure; Change over time is being assessed.
Anxiety Sensitivity Index	baseline, 6 week, 6 month	Change over time is being assessed.
Panic Disorder Severity Scale	baseline, 6 week, 6 month	Change over time is being assessed.
Penn State Worry Questionnaire	baseline, 6 week, 6 month	Change over time is being assessed.

Trial Locations

Locations (2)

Matrix Institute on Addictions; 🇺🇸 Los Angeles, California, United States

University of California-Los Angeles, Department of Psychiatry and Biobehavioral Sciences; 🇺🇸 Los Angeles, California, United States