Preventive effect of ibuprofen on the spasms of brain arteries following brain hemorrhage

Phase 3

Completed

• Conditions: Vasospasms following aneurysmal subarachnoid hemorrhage; Circulatory System

• Registration Number: ISRCTN14611625
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35414560/ (added 06/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-08-19
• Study Completion: 2022-07-29
• Last Update Posted: 18 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Aneurysmal subarachnoid hemorrhage verified by a brain CT scan
2. Older than 18 years old
3. Admitted less than 6 hours after the onset of clinical symptoms
4. World Federation of Neurological Surgeons (WFNS) score I, II and III at admission

Exclusion Criteria

1. Patients who have hypersensitivity to aspirin, ibuprofen or other NSAIDs
2. Previous and prolonged use of any type of NSAIDs other than aspirin
3. History of aneurysmal re-bleeding, and active bleeding of a gastrointestinal ulcer, hemodynamic instability, and pregnancy
4. Patients with a history of myocardial infarction(MI) or percutaneous coronary interventions

Study & Design

• Study Type: Interventional
• Study Design: Not specified