Evidence based evaluation and effect mechanism of traditional Chinese medicine in prevention and treatment of sepsis
- Conditions
- Sepsis
- Registration Number
- ITMCTR2100005295
- Lead Sponsor
- onghua Hospital Shanghai University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1.According to sepsis 3.0 diagnostic criteria;
2.Aged >= 18 and <=80 years;
3.Sign informed consent.
1.The time of definite diagnosis of sepsis was more than 48 hours;
2.Pregnant and lactating women;
3.Serious primary diseases that affect survival, including failed to control multiple metastases that could not be resected, hematological diseases, HIV, etc.;
4.Patients with liver or kidney dysfunction whose SOFA score of liver or kidney was more than 3;
5.Persistent use of immunosuppressants or organ transplantation in the past 6 months;
6.Patients had been treated with hormone continuously for 7 days before entering the group and converted to methylprednisolone dose>=20mg/day;
7.Patients participated in other clinical trials within 30 days;
8.The patients were in critical condition (sofa>=15 or APACHE II>=30) and/or refused active treatment;
9.Known to be allergic to Xuebijing or allergic constitution.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SOFA score improvement;
- Secondary Outcome Measures
Name Time Method 28 day all cause mortality;Duration of mechanical ventilation;Length of stay in ICU;APACHE II score improvement;