Evidence-Based Evaluation and Effect Mechanism of Traditional Chinese Medicine on the Prevention and Treatment of Sepsis Based on Truncated Torsion Strategy
- Conditions
- sepsis
- Registration Number
- ITMCTR2100004722
- Lead Sponsor
- ongHua Hospital Shanghai University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1.The age of patients should be between 18 and 80 years old;
2.Meet the diagnostic criteria of 2016 international guidelines for severe sepsis and septic shock;
3.Voluntarily participate in the experiment and sign the informed consent.
1.The time of definite diagnosis of sepsis was more than 48 hours;
2.Patients with liver or kidney dysfunction whose SOFA score of liver or kidney was more than or equal to 3;
3.The patient is expected to die within 48 hours, or sofa >= 15, or Apache II >= 30, or the patient refuses active treatment;
4.Patients with allergy to traditional Chinese medicine and allergic constitution in this study;
5.Patients with malignant tumor, liver cirrhosis, chronic renal failure (uremic stage), hematological diseases, HIV and other serious basic diseases;
6.Patients who have been treated with hormone, immunosuppressant and other drugs or have organ transplantation in recent 6 months;
7.Those who have participated in other clinical trials at the same time or within 30 days;
8.Pregnant and lactating women.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sequential Organ Failure Assessment Score;28 day mortality;
- Secondary Outcome Measures
Name Time Method Improvement of TCM syndrome integral;Duration of mechanical ventilation;Length of Stay;Acute Physiology and Chronic Health Evaluation II Score;