Research on Effective Procedure Techniques for Very Long-standing Atrial Fibrillatio

Not Applicable

Conditions: Diseases of the circulatory system

Registration Number: KCT0008764

Lead Sponsor: Asan Medical Center

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot yet recruiting

Sex: All

Target Recruitment: 69

Inclusion Criteria

Adults aged between 18-85
Diagnosed with persistent atrial fibrillation lasting for more than 7 days, as confirmed by a 12-lead ECG, Holter monitor, event recorder, or exercise stress test
Patients who have been diagnosed with atrial fibrillation for more than 3 years but less than 10 years
Resistant to or having side effects from one or more class I or III antiarrhythmic drugs
Patients receiving their first (de-novo) catheter ablation procedure for atrial fibrillation

Exclusion Criteria

Refusal to participate in the research
BMI = 35kg/m^2
Intracardiac thrombus
Contraindications to anticoagulant therapy
History of surgical or interventional treatment for atrial fibrillation
Severe valvular heart disease, aortic stenosis, or mechanical prosthetic valve
Anteroposterior diameter of the left atrium of 60mm or more
NYHA class IV heart failure
Thoracic surgery within the last 3 months
Planned thoracic surgery within the next 3 months
End-stage heart failure or severe renal failure (estimated glomerular filtration rate [MDRD method] < 30mL/min/1.73m)
Pregnant or breastfeeding women
Acute coronary syndrome within the last 3 months
Dementia
Co-morbidity (such as ongoing cancer treatment) with expected survival of less than 1 year

Study & Design

Study Type: Observational Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The occurrence rate of atrial tachyarrhythmia (including atrial fibrillation, atrial flutter, and atrial tachycardia) lasting for more than 30 seconds after the 3-month blanking period following the initial procedure

Secondary Outcome Measures

Name	Time	Method
The occurrence rate of all types of atrial arrhythmias, including atrial fibrillation, atrial tachycardia, or atrial flutter, each lasting more than 30 seconds and confirmed by ECG, occurring within 1 year after the 3-month blanking period post-procedure, regardless of medication use;All types of atrial arrhythmia events occurring during the 3-month blanking period after the procedure;Total procedure time (min), total radiation time (min);Success rates of pulmonary vein isolation or each linear ablation;The proportion maintaining sinus rhythm at 6 months and 12 months follow-up;Complications related to the procedure (stroke, pericardial effusion, pulmonary vein stenosis, esophageal injury, death) ;Occurrence of bradyarrhythmic events causing hemodynamic issues and the need for pacemaker insertion;Whether re-intervention or surgery was required