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Clinical Trials/NCT02765035
NCT02765035
Completed
N/A

A Randomized, Blinded, Cross-over Trial to Evaluate the Safety, Functional Mobility and Satisfaction of the Microprocessor Controlled Prosthetic Knee Component C-Leg 4 in Transfemoral Amputees

Otto Bock Healthcare Products GmbH2 sites in 2 countries18 target enrollmentApril 2016

Overview

Phase
N/A
Intervention
Not specified
Conditions
Lower Limb Amputation Above Knee (Injury)
Sponsor
Otto Bock Healthcare Products GmbH
Enrollment
18
Locations
2
Primary Endpoint
Change in 6 Minute Gait Test
Status
Completed
Last Updated
4 years ago

Overview

Brief Summary

The aim of this post-market study is to confirm that the microprocessor controlled prosthetic knee components (C-Leg 3 and C-Leg 4) in comparison to mechanical knee joints can bring additional benefit to the users primarily on level walking and secondarily in safety, stair and hill mobility, activities of daily living, satisfaction and preference.

Detailed Description

During the last two decades many microprocessor controlled knee joints (MPK) appeared on the market.The newly developed C-Leg 4 aims to provide improved standing function while in the same time offering technology of knee´s previous version (C-Leg 3). Since added functional benefit of a knee joint cannot be anticipated just due to the fact that the knee is controlled by the microprocessor, the aim of this post-market study is to evaluate the safety, functional mobility and satisfaction of the microprocessor controlled prosthetic knee components C-Leg 3 and C-Leg 4 in comparison to mechanical knee joints. Additional goal is to improve the methodological quality of research conducted in the field.

Registry
clinicaltrials.gov
Start Date
April 2016
End Date
May 30, 2018
Last Updated
4 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Person is \>18 years old.
  • Person is a unilateral transfemoral or knee-disarticulation amputee with stabilized residual limb.
  • Person is a K2, K3 or K4 ambulator based on Medicare Functional Classification Level (MFCL).
  • Person is currently fitted with a prosthesis using a non-microprocessor controlled prosthetic knee for at least 6 months.
  • Person was never fitted with microprocessor controlled prosthetic knee joint.
  • Person is willing and able to independently provide informed consent.
  • Person is willing to comply with study procedures.
  • Person wears prosthesis daily and ≥ 8 hours/day.
  • Person is walking on average 1km/day.
  • Person is walking not slower than 3km/h (\~0.8m/s) (based on 10m walk test conducted during recruiting).

Exclusion Criteria

  • Person is under 18 years of age.
  • Person who weighs more than 136kg.
  • Person who weighs less than 50kg.
  • Person who is pregnant.
  • Person has a history of chronic skin breakdown on the residual limb.
  • Person has conditions that would prevent participation and pose increased risk (e.g. unstable cardiovascular conditions that preclude physical activity such as walking).
  • Person falls ≥ once a week due to the reasons that could not be corrected by the new prosthesis (for ex. problems with vestibular system).
  • Person is using under arm axillary crutches or walker.
  • Person in an emergency, life threatening situation.
  • Person is unwilling/unable to follow instructions.

Outcomes

Primary Outcomes

Change in 6 Minute Gait Test

Time Frame: Baseline and after acclimation period (30-90 days after fitting)

A measure of walking endurance, the distance walked in meters after 6 minutes.

Secondary Outcomes

  • Change in Stairs Assessment Index (SAI)(Baseline and after acclimation period (30-90 days after fitting))
  • Change in Hill Assessment Index (HAI)(Baseline and after acclimation period (30-90 days after fitting))
  • Change in Prosthetic Limb Users Survey of Mobility (PLUS-M)(Baseline and after acclimation period (30-90 days after fitting))
  • Change in Number of Stumbles and Falls(Baseline and after acclimation period (30-90 days after fitting))
  • Preference of the Knee (Percentage of Subjects That Preferred Each Studied Knee)(At 3rd study visit after having been fitted and acclimatized to each of the study devices)
  • Change in Four Step Square Test (FSST)(Baseline and after acclimation period (30-90 days after fitting))
  • Change in 10 Meter Gait Test(Baseline and after acclimation period (30-90 days after fitting))
  • Change in Activities-specific Balance Confidence (ABC) Scale(Baseline and after acclimation period (30-90 days after fitting))
  • Change in Amputee Body Image Scale (ABIS)(Baseline and after acclimation period (30-90 days after fitting))

Study Sites (2)

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