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Clinical Trials/NCT04784429
NCT04784429
Active, not recruiting
Not Applicable

Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population

Otto Bock Healthcare Products GmbH90 sites in 1 country107 target enrollmentJune 11, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Lower Limb Amputation Above Knee (Injury)
Sponsor
Otto Bock Healthcare Products GmbH
Enrollment
107
Locations
90
Primary Endpoint
Fear of Falling Avoidance Behavior Questionnaire (FFABQ)
Status
Active, not recruiting
Last Updated
2 years ago

Overview

Brief Summary

Two-phased randomized controlled trial comparing the impact of microprocessor controlled knee prostheses (MPK) with the impact of non-microprocessor controlled knee prostheses (NPMK) in patients with a transfemoral/knee disarticulation level amputation categorized as K2 ambulators.

Detailed Description

Randomized controlled trial investigating the benefits of microprocessor controlled knee prostheses (MPK) in patients with a transfemoral or knee disarticulation level amputation categorized by Medicare Functional Classification Level (MFCL) as a Limited Community Ambulator (K-Level 2). There are two aims for the study. Aim 1 is to understand the effect of MPK technology for the K2 ambulator on reducing fear and anxiety of falling, improving health-related quality of life, and participation in society and activities. Aim 2 is to understand the long-term effect of MPK technology the aspects from Aim 1 as well as reducing morbidity. The trial will be conducted in two phases. Phase 1 will cover the initial 12-month period to address Aim 1, and phase 2 will monitor from 12 months to 5 years to address Aim 2.

Registry
clinicaltrials.gov
Start Date
June 11, 2021
End Date
December 31, 2026
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Unilateral transfemoral or knee disarticulation amputation
  • Received prosthesis between 4 - 24 months prior
  • Currently uses prosthesis
  • K2 ambulator status
  • Able to speak English or Spanish language
  • Age ≥ 65 years at Baseline Assessment (one month after enrollment)
  • Minimum Socket Comfort Score (SCS) of 6/10

Exclusion Criteria

  • Upper limb involvement
  • Individuals ≥ 275 lbs
  • Unable to provide informed consent
  • History of acute or chronic residual limb breakdown
  • History of 2 or more socket adjustments or replacements in the past 6 months
  • Amputation of the contralateral limb
  • Active malignancy
  • Rapidly declining health status resulting in reduced activity in the past 6 months, as determined by patient's clinician and confirmed by Clinical \& Scientific Affairs personnel
  • Patient unable or unwilling to follow study procedures
  • Pregnant women, institutionalized persons, and children

Outcomes

Primary Outcomes

Fear of Falling Avoidance Behavior Questionnaire (FFABQ)

Time Frame: 5 years

This is a 14 item survey assessment originally developed with community-dwelling older adults which measures the degree to which respondents avoid activities due to their fear of falling. Responses are on a 5-point scale with 0 = completely disagree and 4 = completely agree. The total possible score is 56 points. A higher score indicates a greater activity limitation and participation restriction as a result of the fear of falling.

Secondary Outcomes

  • Patient-Reported Outcomes Measurement Information System (PROMIS) - Ability to Participate in Social Roles and Activities (APSRA)(3 years)
  • Patient-Reported Outcomes Measurement Information System (PROMIS) - 29(3 years)
  • Average daily step counts(12 months)
  • 12-month fall count from bi-weekly fall journal(12 months)
  • Fear of Falling Avoidance Behavior Questionnaire (FFABQ)(3 years)
  • 10-meter Walk Test (10mWT)(3 years)
  • Timed Up and Go (TUG)(3 years)

Study Sites (90)

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