Comparison of Intralesional Triamcinolone Versus Verapamil for Keloid Treatment

Phase 4

Not yet recruiting

• Conditions: Keloid Scars
• Interventions: Drug: Verapamil Injection; Drug: Triamcinolone Acetonide 1 ml of 40 mg/mL suspension

• Registration Number: NCT06897969
• Lead Sponsor: Nishtar Medical University

Brief Summary

This study aims to compare the efficacy of intralesional triamcinolone and verapamil in patients presenting with keloid at our local setting. The results will guide us towards better management of keloids by choosing the more appropriate treatment. Adequate treatment will reduce significant emotional and physical distress in patients. We hypothesized that mean reduction in Vancouver Scar Score is higher in triamcinolone acetonide group compared to verapamil after three months of treatment.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-20
• Study First Submitted QC: 2025-03-20
• Last Update Submitted: 2025-03-26
• Study First Posted: 2025-03-27
• Study Start: 2025-04-01
• Last Update Posted: 2025-04-01
• Primary Completion: 2025-09-30
• Study Completion: 2025-09-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• size of keloid1-5 cm,
• on any site of the body,
• duration less then five years and
• baseline Vancouver scar score of more the or equal to 5

Exclusion Criteria

• Pregnant or lactating women,
• family history of keloids,
• acromegaly, and
• congestive cardiac diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Verapamil Treatment	Verapamil Injection	One ml (2.5 mg) of Intralesional Verapamil Injection will be administered monthly. The injections will be administered with an insulin syringe of 27-gauge needle. Administration of the treatment medication will be continued till the keloid is flattened or TOTAL DURATION of three months.
Triamcinolone Treatment	Triamcinolone Acetonide 1 ml of 40 mg/mL suspension	Intralesional Triamcinolone acetonide (40mg) will be administered monthly. The injections will be administered with an insulin syringe of 27-gauge needle. Administration of the treatment medication will be continued till the keloid is flattened or TOTAL DURATION of three months.

Primary Outcome Measures

Name	Time	Method
Change in Vancouver Scar Score	Vancouver Scar score will be measured at baseline (before treatment assignment) and then 4-weeks after completion of treatment - 16-weeks after randomization.	The Vancouver Scar scale assesses four parameters of vascularity, pigmentation, pliability and height. The total score ranges from 0 - 13.

Trial Locations

Locations (1)

Nishtar Medical University & Hospital; 🇵🇰 Multan, Punjab, Pakistan