LRRK2 G2385R Leucocyte and Urine Biomarker Study
- Conditions
- Parkinson Disease
- Interventions
- Other: This is a non-interventional study
- Registration Number
- NCT04436848
- Lead Sponsor
- University of Malaya
- Brief Summary
Given the emerging evidence on LRRK2-related biomarkers, this project will focus on identifying leucocyte and urine biomarkers that are altered by the LRRK2 G2385R variant, and investigating the effects of LRRK2 kinase inhibitor (MLi-2) on these biomarkers, using immunoblotting and mass spectrometry.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Diagnosis of Parkinson's disease assigned by a movement disorder specialist according to clinical diagnostic criteria
- Age above 18 year-old
- Provision of a written informed consent
Exclusion Criteria
- Physical or mental incapacity to complete study protocol
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description PD patients negative for LRRK2 G2385R This is a non-interventional study - Non-PD controls negative for LRRK2 G2385R This is a non-interventional study - PD patients positive for LRRK2 G2385R This is a non-interventional study -
- Primary Outcome Measures
Name Time Method Identification of monocyte-based biomarkers for LRRK2 G2385R variant Two years Identification of urine-based biomarkers for LRRK2 G2385R variant Two years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia