COMPARISON OF RATE OF TOOTH MOVEMENT USING MINIMALLY INVASIVE PROCEDURE OF MICRO-OSTEOPERFORATION AND PIEZOCISION WITHOUT RAISING FLAP FOLLOWED BY LOW LEVEL LASER THERAPY IN UPPER JAW - A RANDOMISED CLINICAL TRIAL

Phase 1

Not yet recruiting

• Conditions: PATIENTS UNDERGOING ORTHODONTIC TREATMENT WITHOUT ANY MEDICAL CONDITIONS WITH GOOD PERIODONTAL AND GINGIVAL STATUS

• Registration Number: CTRI/2020/05/025252
• Lead Sponsor: AARTI ANANT SETHIA

Brief Summary

An increasing number of patients are demanding orthodontic treatment for improved aesthetics as it affects their professional and social life. But one of the main challenges of orthodontic treatment faced by the patients and the orthodontists is the prolonged treatment duration. Long duration of fixed orthodontic treatment, which usually lasts for 2-3 years, is accompanied by side effects such as root resorption, gingival inflammation and dental caries.1For rapid canine retraction ,various researchers proposed different surgical techniques such as dentoalveolar distraction-based on principles of distraction osteogenesis, selective alveolar decortication etc.3 But all these surgical procedures lead to increase risk of  tissue necrosis. Later to identify minimally invasive surgical procedures for inducing RAP researchers have introduced micro-osteoperforation, to Control the micro-trauma micro-osteoperforations (MOP) will amplify the expression of inflammatory markers that are normally expressed during orthodontic treatment and that this amplified response will accelerate both bone resorption and tooth movement.5 Recently kim et al and Dibart et al introduced a minimally invasive technique , piezocision as an alternative to the highly invasive surgical techniques which involves the use of scalpel into the gingiva  without raising the flap and further placement of incisions using an ultrasonic tool.1Low-level visible red or infrared light energy is absorbed by mitochondria, which stimulates cells to generate more energy in the form of ATP and help undergo self-repair through cell proliferation, release of growth factors and collagen synthesis. This phenomenon is also known as **Photobiomodulation (PBM) therapy**.With regards to orthodontic tooth movement, the effects of the LLLT on osteoblasts, osteoclasts and fibroblasts are of more interest. LLLT shows a biostimulatory effect on osteoblasts with an increase in their differentiation, DNA replication and bone matrix production. Also, LLLT facilitated that LLLT facilitated differentiation and activation of osteoclasts via RANK expression and stimulation of expression of Macrophage colony-stimulating factor (M-CSF) and its receptor system.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-21
• Last Update Posted: 2020-11-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• 1.Both male and female patients in the age group of 16-35 years.
• 2.Subjects requiring right and left upper first premolar extraction followed by bilateral canine retraction as a part of orthodontic treatment.
• 3.Probing depth values not exceeding 3mm across the entire dentition.
• 4.Adequate thickness of the attached gingiva (1-2mm) 5.No radiographic evidence of bone loss.

Exclusion Criteria

• 1.History of previous orthodontic treatment.
• 2.Periodontally compromised patients.
• 3.Medically compromised patients or patients with systemic disease that might have affected bone formation or density such as osteoporosis, hyperparathyroidism or vitamin D deficiency.
• 4.Patients on any kind of long term medication.
• 5.Subjects indicated for extraction of any tooth other than first premolars for orthodontic treatment.
• 5.Patients with unilateral chewing/ parafunctional habits, crossbites and occlusal interferences.
• 6.Impacted canine or canine with dilacerated roots.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TO COMPARE BETTER CHOICE OF METHOD FOR ACCELERATING TOOTH MOVEMENT WITH AN ADDITIONAL ADJUNCT LOW LEVEL LASER THERAPY	Assessment:0 day | after 1 month | after 2 month | laser dosage | pre-surgical laser dose | immediately after the procedure of micro-osteoperforation and piezocision | day3,4,5 -Analgesic protocol of laser | day-7,14,28,56-Healing protocol of laser

Secondary Outcome Measures

Name	Time	Method
TO COMPARE BETTER CHOICE OF METHOD FOR ACCELERATING TOOTH MOVEMENT WITH AN ADDITIONAL ADJUNCT LOW LEVEL LASER THERAPY	Assessment:0 day

Trial Locations

Locations (1)

KLE VISHWANATH KATTI INSTITUTE OF DENTAL SCIENCES; 🇮🇳 Belgaum, KARNATAKA, India

KLE VISHWANATH KATTI INSTITUTE OF DENTAL SCIENCES

🇮🇳Belgaum, KARNATAKA, India

AARTI ANANT SETHIA

Principal investigator

9769590851

aarti2701@gmail.com