Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome
- Registration Number
- NCT03604198
- Lead Sponsor
- Corcept Therapeutics
- Brief Summary
This is an open-label extension study to evaluate the long-term safety of relacorilant in patients with endogenous Cushing syndrome who successfully completed participation in a Corcept-sponsored study of relacorilant and may benefit from continuing treatment.
- Detailed Description
This study is designed to allow continued therapy with relacorilant, a potent, selective glucocorticoid receptor (GR) antagonist in patients who have successfully completed participation of a Corcept-sponsored study of relacorilant (referred to as the "parent" study). Patients may qualify to enter this extension study if they complete their last treatment visit in their parent study and in the Investigator's opinion will benefit from continued treatment.
Once-daily dosing with relacorilant may continue for patients who receive clinical benefits (as judged by the Investigator) until relacorilant is commercially or otherwise available or the study is stopped by the Sponsor. A patient's dose may be maintained, reduced, or increased based on individual response and tolerability.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 125
-
Major Inclusion Criteria:
- Have completed a Corcept-sponsored study of relacorilant in endogenous Cushing syndrome with at least 80% compliance with the dosing schedule.
- According to the Investigator's opinion will benefit from continuing treatment with relacorilant
-
Major Exclusion Criteria:
- Premature discontinuation from a relacorilant parent study.
- Has uncontrolled, clinically significant hypothyroidism or hyperthyroidism
- Has poorly controlled hypertension
- Has Stage ≥ 4 renal failure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description relacorilant (CORT125134) relacorilant -
- Primary Outcome Measures
Name Time Method Long-term safety of relacorilant 36 months Number of participants with treatment-emergent adverse events (TEAEs)as assessed by CTCAE v4.0
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (49)
Site 49
🇺🇸Phoenix, Arizona, United States
Site 35
🇺🇸Stanford, California, United States
Site 39
🇺🇸Torrance, California, United States
Site 50
🇺🇸Miami, Florida, United States
Site 10
🇺🇸Atlanta, Georgia, United States
Site 9
🇺🇸Chicago, Illinois, United States
Site 1
🇺🇸Indianapolis, Indiana, United States
Site 5
🇺🇸Metairie, Louisiana, United States
Site 27
🇺🇸Baltimore, Maryland, United States
Site 13
🇺🇸Fall River, Massachusetts, United States
Scroll for more (39 remaining)Site 49🇺🇸Phoenix, Arizona, United States