Effects of Different Types of Anaesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery

Not Applicable

Completed

• Conditions: Disk Herniated Lumbar; Anesthesia; Intraocular Pressure
• Interventions: Other: Spinal Anesthesia Group; Other: Desflurane Group; Other: Propofol Group

• Registration Number: NCT06070480
• Lead Sponsor: Giresun University

Brief Summary

The aim of this study was to investigate the effects of anaesthesia methods on intraocular pressure during lumbar disc surgery performed in the prone position.

Detailed Description

The study included 75 patients with lumbar disc herniation between the ages of 18-75, with the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into 3 groups: propofol, desflurane, spinal. Intraocular pressure (IOP) was measured at 5 time points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10 minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4: late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic parameters were measured at these time points. Hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.

Study Timeline

• Study Start: 2022-01-05
• Primary Completion: 2023-01-02
• Study Completion: 2023-05-15
• Status Verified: 2023-09
• Study First Submitted: 2023-09-18
• Study First Submitted QC: 2023-09-29
• Last Update Submitted: 2023-09-29
• Study First Posted: 2023-10-06
• Last Update Posted: 2023-10-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• ASA 1-2 according to the American Society of Anesthesiologists (ASA) Classification.

Exclusion Criteria

• Who did not sign the informed consent form,
• patients who required emergency surgery,
• eye surgery recipients,
• subjects with acute or chronic eye diseases other than refractive errors,
• individuals detected to have elevated IOP in preoperative measurements

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Spinal Anesthesia Group	Spinal Anesthesia Group	Intraocular pressure values of the patients operated with spinal anaesthesia were measured
Desflurane Group	Desflurane Group	Intraocular pressure values were measured in patients operated under general anaesthesia with desflurane.
Propofol Group	Propofol Group	Intraocular pressure values were measured in patients operated under general anaesthesia with desflurane.

Primary Outcome Measures

Name	Time	Method
intraocular pressure	Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine	Intraocular pressure was measured a total of 5 times at set time points throughout the procedures.

Secondary Outcome Measures

Name	Time	Method
Mean Arterial Pressure	Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine	Mean Arterial Pressure was measured a total of 5 times at set time points throughout the procedures.
Heart Rate	Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine	Heart Rate was measured a total of 5 times at set time points throughout the procedures.
End Tidal Carbon Dioxide (CO2)	Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine	End Tidal CO2 was measured a total of 5 times at set time points throughout the procedures.

Trial Locations

Locations (1)

Elvan Tekir Yılmaz; 🇹🇷 Giresun, Gi̇resun, Turkey