The Influence of Prone Position for Spinal Surgery on Visual Acuity

Not Applicable

Not yet recruiting

• Conditions: Vision; Disorder, Loss
• Interventions: Procedure: Desflurane Group; Procedure: Propofol Group

• Registration Number: NCT03644641
• Lead Sponsor: University Hospital Hradec Kralove

Brief Summary

This study investigated the effect of desflurane and propofol anesthesia on visual acuity in patients in prone position for spinal surgery. Many trials have investigated the effects of different anesthetic agents on intraocular pressure, propofol may reduce intraocular pressure more than other intravenous anesthetics.

Detailed Description

Perioperative increase in intraocular pressure can be caused by prone positioning. In addition to surgical factors, patients with glaucoma, uncontrolled hypertension, arthrosclerosis, and morbid obesity are at risk for potentially damaging optic nerve and loss of optic nerve function. Some studies found that intraocular pressure values were significantly lower in patients undergoing propofol total intravenous anesthesia than in patients undergoing desflurane anesthesia during intraoperative positional changes. Pronounced vasodilatation caused by desflurane might produced hyperaemia with higher intraocular pressure. Hemodynamic response to prone position measured by near-infrared spectroscopy (NIRS) on the prefrontal cortex could determine changes caused by prone position.

Study Timeline

• Study First Submitted: 2018-08-21
• Study First Submitted QC: 2018-08-22
• Study First Posted: 2018-08-23
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-09
• Last Update Posted: 2024-05-10
• Study Start: 2025-11-28
• Primary Completion: 2028-11-30
• Study Completion: 2029-12-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Glasgow Coma scale 15
• American Society of Anesthesiologists (ASA) Physical Status Classification System I-III
• spinal surgery in duration less than 3 hours
• sinus rhythm

Exclusion Criteria

• postoperative artificial ventilation
• serious neurological disease
• lung disease with hypercapnia
• propofol allergy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane Group	Desflurane Group	Induction and anesthesia will be held by using desflurane
Propofol Group	Propofol Group	Induction and anesthesia will be held by using target-control anesthesia with propofol

Primary Outcome Measures

Name	Time	Method
Visual injury	48 hours	worsening of test for visual acuity (Rodenstock)

Trial Locations

Locations (1)

University Hospital Hradec Kralove; 🇨🇿 Hradec Kralove, Czechia