To study the effect of anaesthesia whch is given in vertebral coulumn, on blood flow of an artery of eye using ultrasound of eye, in pregnant women with increased blood pressure and in pregnant women with normal blood pressures undergoing caesarean section delivery.

Not Applicable

• Conditions: Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperiumHealth Condition 2: O141- Severe pre-eclampsia

• Registration Number: CTRI/2022/04/042243
• Lead Sponsor: PGIMER Chandigarh

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 2 May 2022

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1.Control group: 30 Normotensive (age and gestational age matched to cases) pregnant female planned for caesarean section under spinal anaesthesia

2.Study group 2: Severely preeclamptic pregnant females who have received magnesium sulphate planned for caesarean section under spinal anaesthesia

Criteria for severe pre-eclampsia 18

Increased bloodpressure (BP; systolic BP is 140 mmHg or a diastolicBP is 90 mmHginawoman who was normotensiveprior to 20 weeks of gestation) accompanied byproteinuria(0.3 g protein in a 24-hour specimen) or increased BPaccompanied by one ormore severe complications of maternal end organ damage evenin the absence of proteinuria like

1. Renal involvement with creatinine > 90 µmol/L

2. Liver involvement with elevatedtransaminases and/or severe right upper quadrant or epigastric pain.

3. Neurological complications like eclampsia, altered mental status, blindness, strokeor more commonly hyperreflexia whenaccompanied by clonus, severe heada-cheswhenaccompanied by hyperreflexia, and persistentvisual scotomata.

4. Hematological complications (thrombocytopenia,disseminated intravascular coa-gulation or hemolysis)

5. Uteroplacental dysfunction (fetal growth restriction)

Exclusion Criteria

1.Patient Refusal

2. Contraindications of spinal anesthesia

3. Short stature <140 cm

4. Allergy to any drugs used

5. Chronic hypertension, Eclampsia

6. Chronic renal disease, Hyperthyroidism, seizure disorder, noninsulin dependent di-abetes mellitus, severe anemia

7. Twin gestation

8. Autoimmune disorders

9. Presence of ocular injuries or prior ocular surgery.

Study & Design

• Study Type: Observational
• Study Design: Not specified