Acute Exercise and Microvascular Function

Not Applicable

• Conditions: Physical Exertion
• Interventions: Other: Acute Exhausting Exercise (AE)

• Registration Number: NCT02727439
• Lead Sponsor: Josip Juraj Strossmayer University of Osijek

Brief Summary

It is well recognized that chronic exercise protects against the development of cardiovascular diseases. However, the responses of vasculature to acute exercise (AE) are not well known and not consistent in literature. Acute exertional exercise can induce large, transient increases in arterial pressure and development of metabolic acidosis which can be associated with pro-inflammatory response involving oxidant stress and circulating cytokines known to impair endothelial function.

The aim of this study is to test the impact of a single exposure to exhausting training on microvascular reactivity in healthy sedentary subjects and athletes.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02
• Status Verified: 2016-03
• Study First Submitted: 2016-03-18
• Study First Submitted QC: 2016-03-29
• Last Update Submitted: 2016-03-29
• Study First Posted: 2016-04-04
• Last Update Posted: 2016-04-04
• Primary Completion: 2017-05
• Study Completion: 2017-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• healthy volunteers
• active athletes
• lean sedentary subjects

Exclusion Criteria

• drugs that could affect the endothelium
• overweight
• hypertension
• coronary artery disease
• diabetes
• hyperlipidaemia
• renal impairment
• cerebrovascular and peripheral artery disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Athletes	Acute Exhausting Exercise (AE)	Active athletes.
Sedentary Subjects	Acute Exhausting Exercise (AE)	Healthy lean sedentary subjects.

Primary Outcome Measures

Name	Time	Method
Skin microcirculation post occlusive reactive hyperemia	Post occlusive reactive hyperemia - PORH, recorded by Laser Doppler Flowmetry will be measured immediately after acute exhausting training.	Cutaneous microvascular blood flow will be measured by Laser Doppler Flowmetry in response to vascular occlusion (post occlusive reactive hyperemia - PORH) before and after acute exhausting training.
Skin microcirculation acetylcholine induced dilation	Acetylcholine induced dilation (AChID), recorded by Laser Doppler Flowmetry will be measured immediately after acute exhausting training.	Cutaneous microvascular blood flow will be measured by Laser Doppler Flowmetry in response to iontophoresis of acetylcholine (acetylcholine induced dilation, AChID) before and after acute exhausting training.

Trial Locations

Locations (1)

Faculty of Medicine Osijek, Laboratory for Clinical and Sport Physiology; 🇭🇷 Osijek, Croatia