High-intensity Interval Training Enhances Mobilization/Functionality of Endothelial Progenitor Cells and Depressed Shedding of Vascular Endothelial Cells Undergoing Hypoxia

Not Applicable

Completed

• Conditions: Hypoxia
• Interventions: Behavioral: HIT; Behavioral: MCT

• Registration Number: NCT02802462
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

Exercise training improves endothelium-dependent vasodilation, whereas hypoxic stress causes vascular endothelial dysfunction. Monocyte- derived endothelial progenitor cells (Mon-EPCs) contribute to vascular repair process by differentiating into endothelial cells. This study investigates how high-intensity interval (HIT) and moderate intensity-continuous (MCT) exercise training affect circulating Mon-EPC levels and EPC functionality under hypoxic condition. Sixty healthy sedentary males were randomized to engage either HIT (3-minute intervals at 40% and 80%VO2max , n=20) or MCT (sustained 60%VO2max , n=20) for 30 minutes/day, 5 days/week for 6 weeks, or to a control group that did not received exercise intervention (n=20). Mon-EPC characteristics and EPC functionality under hypoxic exercise (HE, 100W under 12%O 2 ) were determined before and after various interventions.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-12
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Study First Submitted: 2016-05-19
• Status Verified: 2016-06
• Study First Submitted QC: 2016-06-13
• Last Update Submitted: 2016-06-13
• Study First Posted: 2016-06-16
• Last Update Posted: 2016-06-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Sedentary life
• Age 20~28

Exclusion Criteria

• Smokers
• Users of medication/vitamins
• Any cardiopulmonary/hematological risk
• Regular exercise habits at least 1 year
• Exposed to high altitudes (>3000 m) for at least 1 year

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High intensity-interval (HIT)	HIT	-
moderate intensity-continuous (MCT)	MCT	-

Primary Outcome Measures

Name	Time	Method
Circulating progenitor cells conten	6 weeks	by flow cytometry before and after rehabilitation circulating progenitor cells conten before and after hypoxic exercise test

Secondary Outcome Measures

Name	Time	Method
Cardiopulmonary fitness	6 weeks