Xanthohumol and Metabolic Syndrome
- Conditions
- Metabolic Syndrome
- Interventions
- Dietary Supplement: Xanthohumol
- Registration Number
- NCT01367431
- Lead Sponsor
- Oregon State University
- Brief Summary
The purpose of this study is to determine the pharmacokinetics (PK) of xanthohumol (XN). Small amounts of xanthohumol occur naturally in hops, used to make beer, and XN is also found in beer itself. Studies in animals have shown that XN can lower blood sugar and blood lipids such as triglycerides, which can contribute to heart disease. The purpose of this study is to see how much of the XN is absorbed into the blood and how fast it leaves the body when taken by mouth. Once the PK study has been done, the investigators' long-term goal is to learn if xanthohumol can lower risk factors for heart disease and type-2 diabetes in humans.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 48
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 20 mg Xanthohumol Single dose 20 mg Xanthohumol 60 mg Xanthohumol Single dose 60 mg Xanthohumol 180 mg Xanthohumol Single dose 180 mg Xanthohumol
- Primary Outcome Measures
Name Time Method Levels of xanthohumol and metabolites. 6 days The outcome measures will be the levels of xanthohumol and its metabolites in blood and urine following a single dose of 20 mg, 60mg, or 180 mg of xanthohumol over a course of six days. These levels will be used to determine the pharmacokinetics of xanthohumol in humans.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oregon Health & Science University
🇺🇸Portland, Oregon, United States