Effects of Xanthohumol on Resting Energy Expenditure and Substrate Oxidation in Healthy Women
- Conditions
- Resting Energy Expenditure
- Registration Number
- NCT05711212
- Lead Sponsor
- University of Bonn
- Brief Summary
The aim of this study is to investigate the effects of Xanthohumol on resting energy expenditure and substrate oxidation in healthy women. It is assumed that resting energy expenditure and fatty acid oxidation is higher after Xanthohumol ingestion.
- Detailed Description
In a crossover design, 16 healthy young women ingest 172 mg micellar solubilized Xanthohumol or placebo in a randomized fashion. During an observational period of 3 hours, the acute effects of Xanthohumol on the resting energy expenditure and substrate oxidation is determined by respiratory gas analysis. An additional 30-minute determination of the resting energy expenditure and substrate oxidation is executed 24 hours after Xanthohumol ingestion. The wash-out period will be 28 days.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 16
- BMI: 18,5 - 24,9 kg/m2
- metabolically healthy
- written consent
- smoking
- low or high blood pressure
- dyslipidemia
- insulin resistance or diabetes mellitus type 1 or type 2
- gastrointestinal diseases (e.g. food intolerances or allergies)
- liver, kidney and/or thyroid diseases
- hepatitis B or C, HIV Infection
- chronic inflammatory diseases
- disordered eating
- psychological diseases
- alcohol and/or drug abuse
- use of medication
- pregnancy or lactating
- participation in another intervention study
- irregular menstrual cycle
- more than 6 hours of sports per week
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Acute Effect on Substrate Oxidation assessed uninterrupted for 3 hours post dose assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent
Prolonged Effect on Substrate Oxidation assessed uninterrupted for 30 minutes 24 h post dose assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent
Prolonged Effect on Resting Energy Expenditure assessed uninterrupted for 30 minutes 24 h post dose calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24hours
Acute Effect on Resting Energy Expenditure assessed uninterrupted for 3 hours post dose calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24 hours
- Secondary Outcome Measures
Name Time Method Acute Effect on Blood pressure 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose given in millimeter mercury
Prolonged Effect on Blood pressure 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose given in millimeter mercury
Acute Effect on Pulse 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose given in beats per minute
Prolonged Effect on Pulse 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose given in beats per minute
Trial Locations
- Locations (1)
University of Bonn
🇩🇪Bonn, Germany
University of Bonn🇩🇪Bonn, Germany