Effects of Micellar Solubilized Xanthohumol on Resting Energy Expenditure and Substrate Oxidation in Healthy Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Acute Effect on Substrate Oxidation
研究概览
简要总结
The aim of this study is to investigate the effects of Xanthohumol on resting energy expenditure and substrate oxidation in healthy women. It is assumed that resting energy expenditure and fatty acid oxidation is higher after Xanthohumol ingestion.
详细描述
In a crossover design, 16 healthy young women ingest 172 mg micellar solubilized Xanthohumol or placebo in a randomized fashion. During an observational period of 3 hours, the acute effects of Xanthohumol on the resting energy expenditure and substrate oxidation is determined by respiratory gas analysis. An additional 30-minute determination of the resting energy expenditure and substrate oxidation is executed 24 hours after Xanthohumol ingestion. The wash-out period will be 28 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI: 18,5 - 24,9 kg/m2
- •metabolically healthy
- •written consent
排除标准
- •low or high blood pressure
- •dyslipidemia
- •insulin resistance or diabetes mellitus type 1 or type 2
- •gastrointestinal diseases (e.g. food intolerances or allergies)
- •liver, kidney and/or thyroid diseases
- •hepatitis B or C, HIV Infection
- •chronic inflammatory diseases
- •disordered eating
- •psychological diseases
- •alcohol and/or drug abuse
- •use of medication
- •pregnancy or lactating
- •participation in another intervention study
- •irregular menstrual cycle
- •more than 6 hours of sports per week
结局指标
主要结局
Acute Effect on Substrate Oxidation
时间窗: assessed uninterrupted for 3 hours post dose
assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent
Prolonged Effect on Substrate Oxidation
时间窗: assessed uninterrupted for 30 minutes 24 h post dose
assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent
Prolonged Effect on Resting Energy Expenditure
时间窗: assessed uninterrupted for 30 minutes 24 h post dose
calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24hours
Acute Effect on Resting Energy Expenditure
时间窗: assessed uninterrupted for 3 hours post dose
calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24 hours
次要结局
- Acute Effect on Blood pressure(0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose)
- Prolonged Effect on Pulse(24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose)
- Prolonged Effect on Blood pressure(24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose)
- Acute Effect on Pulse(0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose)
研究者
Prof. Dr. Sarah Egert
Prof. PhD
University of Bonn