Remote Ischemic Conditioning For Prevention Of Contrast Induced Kidney Injury
Not Applicable
- Conditions
- Health Condition 1: I249- Acute ischemic heart disease, unspecified
- Registration Number
- CTRI/2020/07/026548
- Lead Sponsor
- Indian council of medical research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age � 18 years
2.Awaiting percutaneous coronary intervention (PCI)
3.Serum creatinine of >1.4 mg/dl or an estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73m2 or Pre-PCI Mehran score � 11
Exclusion Criteria
1.Patients on hemodialysis/peritoneal dialysis
2.Recent intravascular contrast exposure (� 2 weeks prior to present admission)
3.Inability to perform remote ischaemic conditioning (RIC) (e.g., bilateral upper limb trauma/amputation, severe ischaemia etc)
4.Pregnancy
5.Hypotension (MAP < 60mmHg)
6.Sepsis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary end-point: <br/ ><br>Incidence of CINTimepoint: At 48 hours
- Secondary Outcome Measures
Name Time Method 1. Incidence of subclinical AKI <br/ ><br>2. Change in serum creatinine from baseline to 48 hours post-PCI (Ã?â?creat) <br/ ><br>3. Change in NGAL levels from baseline to 2 hours post-PCI (Ã?â?NGAL2) and to 6 hours post-PCI(Ã?â?NGAL6) <br/ ><br>4. Need for renal replacement therapy <br/ ><br>5. In-hospital-, 30- and 90-day all-cause mortality and major adverse cardiovascular events (MACE) <br/ ><br>Timepoint: 1. Change in NGAL at 2- and 6-hours post-PCI <br/ ><br>2. Incidence of subclinical AKI and change in creatinine at 24- and 48- hours post_PCI <br/ ><br>3. In-hospital, 30- and 90- day all cause mortality and MACE <br/ ><br>