Dose-response relationship of dietary nitrate-rich beetroot juice on cardiovascular and cognition function in older adults.

Phase 3

Completed

• Conditions: High Blood Pressure; Cognitive decline; Cardiovascular - Hypertension; Cardiovascular - Coronary heart disease; Neurological - Other neurological disorders

• Registration Number: ACTRN12620000005954
• Lead Sponsor: Massey University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-01-08
• Study Completion: 2020-03-12
• Last Update Posted: 28 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

Between the ages of 50 - 80y
Healthy individuals
Non-smokers

Exclusion Criteria

Advanced/elite athletes (someone who trains more than four times per week constantly for their sport and competes at a high level)
Taking blood pressure medication
Smokers

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiovascular function (change in mean arterial pressure and systemic vascular resistance via USCOM) <br>composite outcome[Before versus 2.25 hours after consumption of drink];Cognitive function (Cognitive testing and functional near-infrared spectroscopy) cognitive testing included the Corsi block tapering test, rapid visual information processing test, and the Stroop test. <br>Composite outcome[Before versus 2.25 hours after consumption of drink];Blood Pressure (deluxe HEM-7130; OMRON automatic blood pressure machine)[Before versus 2.25 hours after consumption of drink]

Secondary Outcome Measures

Name	Time	Method
Resting metabolic rate (using COSMED gas analysis)[Before versus 2.25 hours after consumption of drink];Mood (mood scales; the profile of mood states, feeling scale and felt arousal scale will be used for mood) <br>Composite Outcome<br>[Before versus 2.25 hours after consumption of drink];Plasma nitrate and nitrite concentrations (via blood sample analysis with HPLC)<br>composite outcome[Before versus 2.25 hours after consumption of drink]