Effectiveness of different modalities for high altitude rapid acclimatization
- Conditions
- Healthy male lowlanders who had not visited high altitude in last 3 years.
- Registration Number
- CTRI/2022/09/045922
- Lead Sponsor
- DEFENCE RESEARCH AND DEVELOPMENTAL ORGANIZATION
- Brief Summary
Exposure at high altitude (HA) induced hypobaric hypoxia is known to deteriorate health and decrease performance. The aim of the study is to develop of Rapid Acclimatization Schedule for HighAltitude in Western sector using different modalities. 400 volunteers within the age range of 20-40 years will be recruited. The volunteers will be randomized into 4 different groups - Control, Drug treated (Acetazolamide), Stay at Moderate Altitude (Short duration) and Intermittent Hypoxia Exposure (IHE). After recording their baseline parameters at Sea Level area they will be inducted to Stage - I HA by air followed by Stage - II HA by road. In all stages differentphysiological, physical and biochemical parameters would be assessed.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Male
- Target Recruitment
- 200
a) Age group: 20 – 40 years b) Medical history: SHAPE – I.
a) Smokers b) Drinker c) Prior induction to HA d) Medical history of any sort.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of Acute Mountain Sickness During the initial days after ascent to high altitude area.
- Secondary Outcome Measures
Name Time Method Exercise Capacity at High Altitude After 48 and 72 hours after reaching high altitude area.
Trial Locations
- Locations (2)
Physiology Laboratory
🇮🇳JAMMU, & KASHMIR, India
Transit Camp, Chandigarh
🇮🇳Chandigarh, CHANDIGARH, India
Physiology Laboratory🇮🇳JAMMU, & KASHMIR, IndiaDr Dharmendra KumarPrincipal investigator9765534896oichamrcleh@gmail.com