Memory formation under stress in humans: Iinvestigation into the importance of hormone receptors.
Completed
- Conditions
- StressCortisolemotional memoryspatial memory
- Registration Number
- NL-OMON19893
- Lead Sponsor
- Radboud University Nijmegen Medical Centre
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 96
Inclusion Criteria
1. Male, healthy volunteers;
2. Age 18 - 35 years;
Exclusion Criteria
1. Anuria;
2. Acute or history of renal insufficiency / impairment of renal excretory function (or creatinine levels > 1.1 mg/dl at screening);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method At the behavioural level, the main study parameter in the spatial memory task is accuracy (i.e. how well subjects remember the right location for a given object learned earlier) and the strategy used (i.e., automatic stimulus response association or elaborate spatial map strategy). For fear acquisition we assess how fast and accurate subjects learn the relationship between specific stimuli and threat using skin conductance responses. At the brain system level, we seek to investigate whether neural response patterns obtained by fMRI can reveal the neural mechanism by which MR activation is causing stress induced changes in spatial memory and fear learning.
- Secondary Outcome Measures
Name Time Method