The role of stress hormones in intentional forgetting
- Conditions
- Not applicable10002861
- Registration Number
- NL-OMON50092
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 180
* Written informed consent
* Good physical and mental health as determined by medical screening
* Age between 18 and 35
* BMI between 17.5 - 28
* Females: use of hormonal contraceptives
* Native language: Dutch, German or English
* A competent level of English to answer the questionnaires
* Willing to eat yoghurt on test day 3
* Diagnosis of a psychiatric disorder (DSM-V)
* Use of any pharmacological treatment at time of inclusion
* Current recreational drug use/dependence
* Current alcohol dependence
* Pregnancy or plans to get pregnant in the near future;
* Contraindications to metyrapone or propranolol
o Propranolol:
* - Diagnosis of a neurological or cardiac disease
* - Obstructive respiratory disease
* - Hypotension (diastolic< 60mmHg; systolic< 90mmHg);
* - Chronic renal failure
* - Hyperthyroidism
o Metyrapone
* - adrenal insufficiency
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome is the extent of intentional forgetting in the<br /><br>Imagine/No-Imagine task and the underlying neural correlates assessed with<br /><br>electroencephalography (EEG).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Additional dependent variables are the neuroendocrine stress markers (cortisol<br /><br>and salivary *-amylase (sAA)) and measures of cognitive functioning (i.e.,<br /><br>working memory, inhibition). </p><br>