Effects of low-fat vs high-fat diet on lipid accumulation in liver and skeletal muscle in overweight men.
Completed
- Conditions
- Type 2 diabetes (T2DM), Insulin resistance, Non-Alcoholic Fatty Liver Disease (NAFLD)Type 2 diabetes, insuline resisstentie en leververvetting
- Registration Number
- NL-OMON19938
- Lead Sponsor
- School for Nutrition, Toxicology and Metabolism of Maastricht University Medical centre + (MUMC+)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Male sex;
2. Age 40-65 years;
Exclusion Criteria
1. Current use of medication that is known to interfere with the results of the study;
2. Consuming more than 20 g of alcohol per day (± 2 units);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main study parameter is the difference in lipid accumulation and insulin sensitivity after a switch from a low-fat diet to a high-fat diet compared to the control group, which stays on a low-fat diet.
- Secondary Outcome Measures
Name Time Method As secondary endpoints differences the time-course of lipid accumulation and the relationship between the tissue parameter lipid ccumulation and the functional outcome parameter insulin resistance are considered.