Effects of High Intensity Interval- vs Resistance or Combined- Training for Improving Cognitive Function and Neurotrophic Factors in Overweight Adults (BrainFit Study): Factorial Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change from Baseline in Brain-derived neurotrophic factor
研究概览
简要总结
The BrainFit Study aims to examine acute effects of High Intensity Interval- vs Resistance or Combined program has benefits on Cognitive Function as well as on secretion and regulation of neurotrophic factors or neurotrophins in a cohort of sedentary, overweight adults (aged 18-30 years) from Bogota, Colombia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Written informed consent.
- •Interested in improving health and fitness.
- •Central obesity: waist circumference ≥90cm
- •Body mass index ≥ 26 kg/m(2)
排除标准
- •Systemic infections.
- •Weight loss or gain of >10% of body weight in the past 6 months for any reason.
- •Currently taking medication that suppresses or stimulates appetite.
- •Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
- •Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
- •Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
- •Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
- •Any active use of illegal or illicit drugs.
- •Current exerciser (>30 min organized exercise per week).
- •Indication of unsuitability of current health for exercise protocol (PARQ).
研究组 & 干预措施
High Intensity Interval
One session for 30-60 minutes of high intensity aerobic exercise
干预措施: Experimental: High Intensity Interval (Behavioral)
Resistance training
One session for 30-60 minutes of resistance exercise
干预措施: Resistance training (Behavioral)
Plus: High Intensity Interval + Resistance Training
One session for 30-60 minutes of high intensity aerobic exercise and resistance exercise
干预措施: Plus: High Intensity Interval + Resistance Training (Behavioral)
Non-exercise
Non-exercise
干预措施: Non-exercise (Other)
结局指标
主要结局
Change from Baseline in Brain-derived neurotrophic factor
时间窗: Baseline and 60 minutes immediately after the interventions ends
Measurement of serum Brain-derived neurotropic factor true blood samples.
次要结局
- Change from Baseline in Neurotrophin-3(Baseline and 60 minutes immediately after the interventions ends)
- Change from Baseline in Neurotrophin-4(Baseline and 60 minutes immediately after the interventions ends)
- Change from Baseline change in Cognitive Function(Baseline and 60 minutes immediately after the interventions ends)