The Influence of Excess Adiposity on Cardiorespiratory, Insulin-like Growth Factor, and Metabolic Responses to a Standardized Aerobic Exercise Program in Cancer Survivors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Recruitment
研究概览
简要总结
This is a pilot feasibility study of an investigation of the influence of excess adiposity on cardiorespiratory fitness (CRF), insulin-like growth factor-1 (IGF-1), and metabolic responses to a standardized aerobic exercise program in cancer survivors. This investigation attempts to isolate the influence of adiposity on these responses. We will enroll overweight, obese, and normal weight cancer survivors with a primary diagnosis of breast, prostate, or colorectal cancer who have completed all cancer-related treatment. Participants will engage in a 15-week aerobic exercise intervention with pre- and post-intervention assessments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary cancer diagnosis of breast, prostate, or colorectal cancer
- •Completion of all cancer-related treatment > than 6 months prior and < 5 years prior to enrollment
- •Ability and willingness to participate in a supervised exercise program
- •All participants will be required to obtain a signed physician clearance to participate in exercise form prior to enrollment
排除标准
- •Presence of a secondary active cancer diagnosis or metastatic disease
- •Any current cancer treatment (including hormonal treatment) or planned cancer treatment in the next 5 months
- •Greater than 100 min of self-reported regular exercise per week
- •BMI < 18.5 (underweight)
- •Any significant metabolic condition, such as diabetes. Individuals with pre-diabetes or metabolic syndrome will not be excluded, but this information will be recorded.
- •Any medical condition that would impact the safety of, or participation in, an exercise program or exercise testing, including:
- •Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries
- •Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia
- •Pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease
- •Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months
研究组 & 干预措施
Aerobic exercise
15-week standardized aerobic exercise intervention
干预措施: Aerobic Exercise (Behavioral)
结局指标
主要结局
Recruitment
时间窗: up to 12 months
Number of participants joining the study per month
Study Adherence
时间窗: up to 12 months
Percentage of participants completing pre- and post-intervention assessments
Intervention Adherence
时间窗: 15 weeks
Average percentage of prescribed exercise sessions completed by participants
次要结局
- Total visceral adiposity(Baseline, Week 15)
- Serum IGF-1(Baseline, Week 15)
- Estimated VO2max(Baseline, Week 15)