Checking the effect of nebulised dexmedetomidine on pulmonary blood pressure in cardiac surgeries
Not Applicable
- Registration Number
- CTRI/2022/06/043086
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Inclusion Criteria
1. Age 18-55 years
2. Both genders
3. Elective cardiac surgery
4. Mitral valve repair or replacement
5. Mitral stenosis, mitral regurgitation
6. Coronary artery bypass graft with mitral valve replacement
Exclusion Criteria
EXCLUSION CRITERIA
1. Anticipated difficult airway.
2. Preoperative heart rate < 50 bpm
3. Uncontrolled AF and ventricular rate
4. Second degree heart block and bundle branch blocks
5. Patients with both mitral and aortic valve disease
6. Right atrial mass or thrombus
7. Emergency surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Compare change in pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressures (mPAP) during laryngoscopy and intubation.Timepoint: Within 2 successful intubation attempts
- Secondary Outcome Measures
Name Time Method Compare change in pulmonary vascular resistance (PVR)during laryngoscopes and intubationTimepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation;Compare dose of inotropes or vasopressors requiredTimepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation;Compare dose of propofol and fentanyl required during intubation response to optimise blood pressureTimepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation;Compare PASP and systolic blood pressure (SBP) ratio (PASP/SBP) during laryngoscopy and intubationTimepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation;Compare PASP, PADP, mPAP, PVR, SBP, DBP, MAP, systemic vascular resistance, cardiac output (CO) and cardiac index (CI)Timepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation