Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan
试验速览
- 阶段
- 不适用
- 入组人数
- 84
- 主要终点
- Is patient outcome in terms of survival or death at discharge.
研究概览
简要总结
evaluate the Efficacy of high flow nasal oxygen as a weaning strategy in mechanically ventilated patients with respiratory failure.
详细描述
Acute respiratory failure is a main cause of IMV and admission to intensive care unit (ICU){1}.
The day of extubation is a critical time during an intensive care unit (ICU) stay because in case of postextubation failure {2},which reach to 25 - 40% from extubated patient associated with VAP and barotrauma, mortality rate and hospital stay will increase , we use Adjuvant oxygen therapy to prevent these undesirable event like COT ,NIV and High-flow nasal cannula (HFNC) which can be used as an initial weaning strategy from IMVdue to its physiologic benefits [3-4].
HFNC devices supply between 30 and 60 L/min of a controlled mixture of actively warmed (32-37 °C) and humidified (up to 100% relative humidity) oxygen and air through modified nasal prongs. producing {5-6-7}:
- moderate positive end-expiratory pressure (PEEP) .
- HFNC might help prevent extubation failure through different
Mechanisms:
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1- All adult patients who were admitted to our ICU requiring endotracheal intubation (ETI), were eligible for the study.
排除标准
- •Non-intubated patients or those with tracheostomy were excluded from the study.
- •those having neurological alteration unrelated to hypercapnoeic encephalopathy, cranio-facial deformity, upper airway obstruction, cardiogenic pulmonary edema, cardiogenic shock, acute myocardial infarction, pneumothorax, pulmonary neoplasm, pulmonary thromboembolism, gastrointestinal bleeding, and post-operative respiratory failure.
- •Patients less than 18 y.
结局指标
主要结局
Is patient outcome in terms of survival or death at discharge.
时间窗: through study completion average 7 days.
evaluate the Efficacy of high flow nasal oxygen as a weaning strategy in mechanically ventilated patients with respiratory failure as regarding Hospitalization ,complications, oxygenation , reintubation rate, mortality rate.
次要结局
- Duration of ICU stay through study completion average 7 days ,Adverse events.(through study completion average 7 days.)
研究者
Hamed Farag Qenawy Ahmed
Principal investigator
Assiut University