Determination of glycemic index of dietary fibre enriched meal choices-aloo paratha and Idly

Not yet recruiting

Conditions: Healthy participants with normal body mass index

Registration Number: CTRI/2023/09/057479

Lead Sponsor: Madras Diabetes Research Foundation

Brief Summary: Research studies have shown thatlifestyle; in particular dietary aspects play an important role in preventing /increasing the burden of the chronic diseases. Dietary habits could thereforebe modified to exert a positive impact in the prevention and treatment. It hasbeen suggested that the high glycemic carbohydrate foods -those foodscontaining carbohydrates which elicit rapid blood glucose rise and therebyincrease the insulin demand leading to hyperinsulinemia, insulin resistance andtype 2 diabetes. Hence, there is a need to understand the blood glucose raisingpotential of foods in India to be of an important tool to aid in the preventionand or management of diabetes and its complication. Thus, evolved the conceptof â€˜Glycemic Indexâ€™ (GI) which ranks the foods, based on the speed at which thefood raises the blood glucose in a scale of 0 to 100, 100 indicating highglycemic index corresponds to oral glucoseâ€™s GI. Today, India leading the worldwith the largest number of people with daibetes causing a heavy economic burdento the country urgently needs to look at cost effective strategies to combatthis situation. A cost-effective dietary approach like estimating andunderstanding the role of glycemic index of various Indian foods in thelifestyle related diseases like diabetes is urgently needed.

Incorporation of dietary fibre inhigh carbohydrate foods has been identified as a strategy to reduce theglycemic index of foods. Intake of dietary fibre increase stomach distension,which increases satiety and slows nutrient absorption. Furtherintake of dietary fibre can favorably influence the change in gut hormonelevels that act locally and, in the brain, to affect eating behavior. Ingestionof fibers like FibersolÂ®-2 increases peptide YY (PYY), which decreases appetiteby slowing gastric motility and inhibiting pancreatic secretion. It alsoincreases glucagon-like peptide-1 (GLP-1), which increases insulin secretionand sensitivity and inhibits gastric acid secretion and emptying, thusincreasing satiety signals in the brain. Hence, the present study was carriedout with the following objectives.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

BMI greater than 18.5 to less than 22.9 kg/ m2 (as per WHO cut off for normal BMI) Both male and female Willingness to consume the test foods no known food allergy or intolerance; no medications known to affect glucose tolerance (excluding oral contraceptives) â€” stable doses of oral contraceptives, acetylsalicylic acid, thyroxin, vitamins, fibre and mineral supplements or drugs to treat hypertension or osteoporosis are acceptable.

Exclusion Criteria

a known history of diabetes mellitus or the use of anti-hyperglycemic drugs or insulin to treat diabetes and related conditions pregnant or lactating women a major medical or surgical event requiring hospitalization within the preceding 3 months; the presence of disease or drug(s) which influence digestion and absorption of nutrients; the use of steroids, protease inhibitors or antipsychotics, prebiotics, and probiotics (all of which have major effects on glucose metabolism and body fat distribution) from past 30 days.
Regular use of supplements that are rich in dietary fiber or protein which influences the satiety assessment.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
glycemic index, GI category of food preparations without & with dietary fibre enrichment	Capillary blood samples will be collected at -5,0 minutes before consumption of test and reference foods and 15,30,45,60,90,120,180,240 minutes post consumption of test and reference foods

Secondary Outcome Measures

Name	Time	Method
The study will also elicit, the effect of the food preparations (aloo paratha & idly) without and with dietary fibre enrichment on satiety levels assessed using gut hormones-GLP-1 and PYY levels	Blood samples will be collected at 0 min (fasting), 60-, 120,180- & 240-minutes post consumption of intervention foods and 1 comparator glucose drink to assess selected gut hormones- GLP-1 and PYY

Trial Locations

Locations (1): Madras Diabetes Research Foundation
🇮🇳
Chennai, TAMIL NADU, India
Madras Diabetes Research Foundation
🇮🇳Chennai, TAMIL NADU, India
Sudha Vasudevan
Principal investigator
9840014480
s2r_7@mdrf.in