Individualized Positive End-expiratory Pressure Evaluation Using the Intratidal Compliance-volume Profile in Children

Not Applicable

Completed

• Conditions: Lung Compliance
• Interventions: Procedure: Positive end expiratory pressure (PEEP)

• Registration Number: NCT03533296
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The investigators assess the changes in respiratory compliance according to different levels of positive end expiratory pressure (PEEP) in children under general anesthesia. In addition, the investigators evaluate the intratidal compliance-volume profile at each PEEP level and determine the optimal PEEP level during anesthesia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-05-11
• Study First Submitted QC: 2018-05-11
• Study First Posted: 2018-05-23
• Study Start: 2018-11-13
• Status Verified: 2019-11
• Primary Completion: 2019-11-20
• Study Completion: 2019-12-20
• Last Update Submitted: 2020-03-24
• Last Update Posted: 2020-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 47

Inclusion Criteria

• Children undergoing surgery more than 1 hour under general anesthesia
• American Society Anesthesiologist physical status I, II

Exclusion Criteria

• History of lung resection
• History of bronchopulmonary dysplasia or respiratory distress syndrome
• Abnormalities in chest radiography
• Laparoscopic surgery
• Abdominal surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Children	Positive end expiratory pressure (PEEP)	Children who receive elective surgery under general anesthesia and are supported by mechanical ventilation

Primary Outcome Measures

Name	Time	Method
Mean respiratory compliance	During 15 minutes after applying each level of PEEP	Mean static and dynamic compliance

Secondary Outcome Measures

Name	Time	Method
Compliance profile	During 15 minutes after applying each level of PEEP	We will determine Intratidal compliance-volume profile using the changes in compliance over time; --\> I, merely increasing compliance profile; IH, increasing turning into horizontal compliance profile; D, merely decreasing compliance profile; HD, horizontal turning into decreasing compliance profile; IHD, increasing turning into horizontal and further turning into decreasing compliance profile; If compliance profile is I, the PEEP is low. On the other hand, compliance profile is D, PEEP level is considered to be high.
Airway resistance	During 15 minutes after applying each level of PEEP	Mean airway resistance

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of