SNEEX - Impact of Olfactory Odour StimulatioN on Energy EXpenditure

University Hospital, Basel, Switzerland1 site in 1 country58 target enrollmentJanuary 18, 2022

ConditionsObesity

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Obesity
Sponsor: University Hospital, Basel, Switzerland
Enrollment: 58
Locations: 1
Primary Endpoint: Change in Energy Expenditure
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In this preliminary short-term study it is investigated, whether a short olfactory stimulation with distinct odours impacts energy expenditure in patients with obesity and lean patients.

Registry

clinicaltrials.gov

Start Date

January 18, 2022

End Date

October 30, 2024

Last Updated

2 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

University Hospital, Basel, Switzerland

Responsible Party

Principal Investigator

Katharina Timper

Principal Investigator, Prof. Dr. med.

University Hospital, Basel, Switzerland

Eligibility Criteria

Inclusion Criteria

•• Age 18-55 years
•Obesity (BMI ≥30 kg/m2) and Lean (BMI 18-25 kg/m2)
•Written informed consent
•Normosmia (defined by sniffing Sticks test)

Exclusion Criteria

•• Chronic or acute sinusitis
•Surgical intervention of the nasal cavity or the paranasal sinus
•Known allergy to odors used in the study
•Current illicit drug abuse including daily marijuana and cannabidiol (CBD) consumption (alcohol ≤2 drinks per day allowed)
•Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease)
•Diabetes mellitus
•Treatment with insulin sensitizing drugs including Glucagon-like Peptide (GLP)-1 analogues within the last 3 months
•History of neurodegenerative diseases, severe head trauma
•Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2)
•Known liver cirrhosis or other severe liver impairment