Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients With Indirect Signs of Pulmonary Arterial Hypertension
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Scleroderma, Systemic
- Sponsor
- Paul Farand
- Locations
- 1
- Primary Endpoint
- Correlation of a 20 mmhg increase in the pulmonary artery pressures (PAP) during stress echocardiography and PAP using right heart catheterization.
- Status
- Withdrawn
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of this study is to assess the value in terms of sensitivity, specificity and likelihood ratio of the stress echocardiography in the screening of pulmonary arterial hypertension in patients with systemic sclerosis and indirect signs of pulmonary arterial hypertension.
Detailed Description
Pulmonary artery catheterization (rest and exertion) and treadmill stress echocardiography will be done to all patients of the study.
Investigators
Paul Farand
MD
Université de Sherbrooke
Eligibility Criteria
Inclusion Criteria
- •At least one of the prespecified indirect sign of pulmonary arterial hypertension
- •Able to exercise on treadmill
Exclusion Criteria
- •left ventricular dysfunction at rest
- •Absence of pulmonary regurgitant flow
- •Pregnancy or breastfeeding
- •Smoking with \> 60 pack-year
Outcomes
Primary Outcomes
Correlation of a 20 mmhg increase in the pulmonary artery pressures (PAP) during stress echocardiography and PAP using right heart catheterization.
Time Frame: 5 years
Every patient will have both procedures; stress echocardiography and right heart catheterization. A positive stress echocardiography is defined as \>= 20 mmhg increase in the systolic pulmonary artery pressure (SPAP) (between rest and stress) or an absolute value \>= 55 mmhg. A positive right heart catheterization at rest is defined as a PAPm \>25mmhg, wedge \< 18 and pulmonary vascular resistances \>3 wood units. Stress catheterization will also be perform and is defined as a PAPm \> 30mmhg and wedge \<18 mm hg.
Secondary Outcomes
- Correlation of a 20 mmhg increase in the PAP during stress echocardiography and elevated NT-proBNP.(5 years)
- Function of the left ventricle (left ventricular ejection fraction) at rest and at stress.(Follow up every year X 5)
- Diastolic function at rest and at stress(follow up every year X 5)
- Function of the right ventricle(Follow up every year X 5)